Results 331 to 340 of about 443,435 (420)

Advancing Allogeneic NK Cell Immunotherapy through Microfluidic Gene Delivery

open access: yesAdvanced Science, EarlyView.
The Y‐Hydroporator is a microfluidic gene delivery platform designed for allogeneic NK cell‐based immunotherapies. It achieves highly efficient gene delivery while preserving high cell viability and functionality. By producing engineered NK cells with enhanced cytotoxicity, the platform addresses critical limitations of autologous cell therapy ...
Hyelee Kim   +6 more
wiley   +1 more source

Gut Microbiota Colonization in Early Life Influences Susceptibility to Adulthood Hepatic Lipid Accumulation in High‐Fat‐Diet‐Fed Mice

open access: yesAdvanced Science, EarlyView.
This study indicates that perinatal antibiotic exposure elevates susceptibility to high‐fat‐diet‐induced hepatic lipid accumulation via disrupting early‐life gut microbiota colonization. The decreased Lactobacillus colonization inhibits primary‐to‐secondary bile acid conversion, lowering secondary bile acids, enhancing adulthood intestinal lipid ...
Yan‐Yan Zhu   +11 more
wiley   +1 more source

Development of Carbon‐11 Labeled Pyrimidine Derivatives as Novel Positron Emission Tomography (PET) Agents Enabling Brain Sigma‐1 Receptor Imaging

open access: yesAdvanced Science, EarlyView.
Novel carbon‐11 labeled pyrimidine derivatives are developed as PET imaging probes for visualizing sigma‐1 receptors in the brain. [11C]CNY‐01 demonstrates superior brain uptake and binding specificity in both rodents and non‐human primates. The study reveals decreased sigma‐1 receptor expression in Alzheimer's disease, offering a promising tool for ...
Ping Bai   +12 more
wiley   +1 more source

Photopatternable PEDOT:PSS Hydrogels for High‐Resolution Photolithography

open access: yesAdvanced Science, EarlyView.
A photosensitive biphasic conducting polymer hydrogel (PB‐CH) is rationally designed with PEDOT:PSS as the conductive phase and a light‐sensitive matrix as the mechanical phase. Such a PB‐CH offers a unique combination of excellent conductivity (≈30 S cm⁻¹), robust mechanical performance (with stretchability up to 50%), and high photopatternability ...
Wen Wang   +7 more
wiley   +1 more source

Laser Ultrafast Confined Alloying of Sub‐5 nm RuM (M = Cu, Rh, and Pd) Particles on Carbon Nanotubes for Hydrogen Evolution Reaction

open access: yesAdvanced Science, EarlyView.
In this work, the synthesis of carbon nanotubes (CNTs) supported sub‐5 nm dominant intermetallic RuCu, RuRh, and RuPd NPs are succeeded by the proposed method of nanosecond laser ultrafast confined alloying (LUCA), which is featured by its unique ultrafast heating and cooling rates and high stability for long‐term alkaline HER catalysis application ...
Taiping Hu   +9 more
wiley   +1 more source

Diallyl Trisulfide From Garlic Regulates RAB18 Phase Separation to Inhibit Lipophagy and Induce Cuproptosis in Hepatic Stellate Cells for Antifibrotic Effects

open access: yesAdvanced Science, EarlyView.
Diallyl trisulfides (DATs) selectively induce cuproptosis in hepatic stellate cells (HSCs) by targeting Ras‐related protein Rab‐18 (RAB18) and regulating lipophagy. DATs promote RAB18 phase separation, enhance mitochondrial‐associated membrane structures (MAMs) formation, and increase succinylation of dihydrolipoamide dehydrogenase (DLD) at K320.
Haoyuan Tian   +16 more
wiley   +1 more source

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