Results 41 to 50 of about 220,736 (298)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Therapeutic Plasma Exchange—A Practical Guide

Kidney and Dialysis
Therapeutic plasma exchange is a procedure in which plasma is removed and replaced with another fluid to correct blood abnormalities. There is growing evidence of its benefit in certain clinical conditions, including thrombotic thrombocytopenic purpura ...
Mariana Dias Pais, Ana Gaspar, Sílvia Coelho   +2 more
doaj   +1 more source

Plasma Exchange in Patients With Severe Coronavirus Disease 2019: A Single-Center Experience

Critical Care Explorations, 2021
IMPORTANCE:. Recent evidence suggests a multilevel inflammatory syndrome as a driving factor in some of the most severely ill coronavirus disease 2019 patients with overlapping features to other hyperinflammatory or autoimmune diseases. Therefore, plasma
Christian Nusshag, MD, Christian Morath, MD, Claudius Speer, MD, Florian Kaelble, MD, Martin Zeier, MD, Monica Boxberger, MD, Elisa Schulze-Schleithoff, MD, Mascha O. Fiedler, MD, Markus A. Weigand, MD, Uta Merle, MD   +9 more
doaj   +1 more source

Therapeutic Plasma Exchange in Refractory Hyperthyroidism [PDF]

European Thyroid Journal, 2020
Hyperthyroid patients who are unresponsive to medical treatment remain a challenging clinical problem.The goal of our study was to evaluate the use of therapeutic plasma exchange (TPE) in hyperthyroid patients and their outcome after TPE.We retrospectively reviewed 22 patients who underwent TPE for refractory thyrotoxicosis in our institution: 13 with ...
Clotilde, Saïe, Cécile, Ghander, Samir, Saheb, Christel, Jublanc, Denis, Lemesle, Charlotte, Lussey-Lepoutre, Laurence, Leenhardt, Fabrice, Menegaux, Christophe, Tresallet, Camille, Buffet   +9 more
openaire   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The current state of biomarker research for Friedreich's ataxia: a report from the 2018 FARA biomarker meeting [PDF]

, 2019
The 2018 FARA Biomarker Meeting highlighted the current state of development of biomarkers for Friedreich's ataxia. A mass spectroscopy assay to sensitively measure mature frataxin (reduction of which is the root cause of disease) is being developed ...
Blair, Ian A., Farmer, Jennifer, Hersch, Steven, Larkindale, Jane, Lynch, David R., Napierala, Jill, Napierala, Marek, Payne, R. Mark, Subramony, Sub H.   +8 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Plasma exchange in acute and chronic hyperviscosity syndrome: a rheological approach and guidelines study [PDF]

, 2007
Therapeutic plasma exchange is an extra-corporeal technique able to remove from blood macromolecules and/or replace deficient plasma factors. It is the treatment of choice in hyperviscosity syndrome, due to the presence of quantitatively or qualitatively
ALBERTAZZI, Alberto, F. FERRARI, G. MILANTI, GB CECCHERELLI, M. BALLESTRI, M. DE PALMA, M. MARIANO, MAGISTRONI, Riccardo   +7 more
core  

Health technology assessment of pathogen reduction technologies applied to plasma for clinical use [PDF]

, 2016
Although existing clinical evidence shows that the transfusion of blood components is becoming increasingly safe, the risk of transmission of known and unknown pathogens, new pathogens or re-emerging pathogens still persists.
Berrino, Alexandra, Casini, Marina, Cicchetti, Americo, Codella, Paola, Facco, Giuseppina, Fiore, Alessandra, Grazzini, Giuliano, Liumbruno, Giancarlo M., Marano, Giuseppe, Marchetti, Marco, Midolo, Emanuela, Minacori, Roberta, Refolo, Pietro, Romano, Federica, Ruggeri, Matteo, Sacchini, Dario, Spagnolo, Antonio G., Urbina, Irene, Vaglio, Stefania   +18 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source