Results 121 to 130 of about 1,909,516 (350)

Spanning presence and absence. Separation anxiety in the early years. [PDF]

, 2008
Book Synopsis. This volume is the result of over twenty years of therapeutic interventions with families within the Tavistock Clinic's Under Fives Service.
Likierman, Meira
core  

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Advance directives as a care planning tool for patients with complex mental health needs: service evaluation

BJPsych Bulletin
Aims and method This study investigated the prevalence of advance directives among patients receiving community care within the East London NHS Foundation Trust (ELFT), and to identify factors associated with their clinical application.
Immanuel Amrita Rhema, Mohamed Ibrahim, Hajara Begum, Paul Binfield, Doris McMeel, Sophia Parveen, Lara O’Connell, Frank Röhricht   +7 more
doaj   +1 more source

A sinking heart: Whose problem is it? Under fives work in the surgery of a general practitioner. [PDF]

, 2008
Book Synopsis. This volume is the result of over twenty years of therapeutic interventions with families within the Tavistock Clinic's Under Fives Service.
Sternberg, Janine, Tydeman, Beverley
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

“I Am Longing and Afraid to Depend on You”: A Case Report on Breakdowns of Therapeutic Alliance and Interpersonal Cycles in Complex Trauma

Brain Sciences
Background: Patients with Complex Trauma (CT) may have an impaired ability to trust others and build intimate relationships due to non-integrated representations of self and others.
Carolina Papa, Erica Pugliese, Claudia Perdighe, Ramona Fimiani, Francesco Mancini   +4 more
doaj   +1 more source

Brief work with parents of infants [PDF]

, 2008
Book Synopsis. This volume is the result of over twenty years of therapeutic interventions with families within the Tavistock Clinic's Under Fives Service.
Wittenberg, Isca
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The importance of medical patient relationship in therapeutic adherence in people living with type 2 Diabetes [PDF]

, 2019
Viridiana Vázquez Morales, Josefina Reynoso Vázquez, Maricarmen Rivera Gómez, Lorenzo Octavio Aguirre Rembao, Jesús Carlos Ruvalcaba Ledezma   +4 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source