Results 171 to 180 of about 7,872,411 (241)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

The Impact of Coercive Measures on the Therapeutic Relationship Between Patients and Nurses in the Acute Psychiatric Care. An Integrative Review. [PDF]

J Psychiatr Ment Health Nurs
Wostry F, Hahn S, Schrems B.
europepmc   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Impact of the 'Reserved Therapeutic Space' Nursing Intervention on Acute Mental Health Inpatients' Perceptions of the Therapeutic Relationship, Quality of Care, Perceived Coercion and Length of Stay: A Multicentre Quasi-Experimental Trial. [PDF]

J Psychiatr Ment Health Nurs
Roviralta-Vilella M, El-Abidi K, Sanchez-Balcells S, Roldán-Merino JF, Lluch-Canut MT, Garcia-Sanchez JA, Muñoz-Ruoco E, Pérez-Moreno JJ, Pita-De-La-Vega J, Cañabate-Ros M, Rubia-Ruiz G, Santos-Pariente C, Rodrígez López AM, Golmar LJ, Esquinas López C, Ghrijou-Abselam N, Pastor-Bernabeu MV, Puig-Llobet M, Moreno-Poyato AR.   +18 more
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Toward a therapeutic relationship: A randomized control trial of the physical environment and client-centered communication in genetic counseling. [PDF]

J Genet Couns
Broadbridge E, Roter DL, Persky S, Erby LH.   +3 more
europepmc   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Older patients' perspectives on the therapeutic relationship with young psychotherapists. [PDF]

PLoS One
Boschann A, Staats H, Wiegand-Grefe S.
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Development and Psychometric Properties of the Therapeutic Relationship Assessment Scale-Patient (TRAS-Patient). [PDF]

Int J Ment Health Nurs
Coelho JCF, Ribeiro JIF, Ribeiro ARM, Trindade ACG, da Sequeira CA, Roldán Merino JF, Moreno Poyato AR, Sampaio FMC.   +7 more
europepmc   +1 more source