Therapeutic Use of Botulinum Toxin in Neurology: a Literature Review
Botulinum toxin (BTX), a neurotoxin produced by Gram-positive Clostridium botulinum, is widely known for its broad application in aesthetic medicine, but it is also playing an increasingly important therapeutic role in neurology.
Natalia Skrzypska +5 more
core +1 more source
An exploration of the use of language within therapeutic interventions for people experiencing psychosis [PDF]
, 2018 Formulation is a fundamental component in many of the psychological therapies practised within the National Health Service (e.g. cognitive behavioural therapy and psychodynamic therapy) (British Psychology Society, Division of Clinical Psychology, [BPS ...
Gibbs, M.
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
A Review of the Biochemical and Pathophysiological Properties of Curcumin [PDF]
Journal of Mazandaran University of Medical SciencesBackground and purpose: Medicinal plants play a crucial role in maintaining human health and contain various phytochemical compounds recognized as therapeutic active agents.
Sahar Farzaneh +4 more
doaj
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Resistencia de levaduras del género Candida al fluconazol Candida yeast´s resistance to fluconazol
Infectio, 2010 Las infecciones por levaduras del género Candida sp. son cada vez más prevalentes en pacientes hospitalizados, especialmente en grupos de mayor riesgo como pueden ser pacientes con neoplasia hematológica bajo tratamiento de quimioterapia y en cuidados ...
Carlos Hernando Gómez Quintero
doaj
Therapeutic interventions: an Islamic perspective [PDF]
, 2008 Disease and its healing in most of the therapeutic strategies are mainly based either on physical or metaphysical aspects. Therapeutic strategies in Islam, on the other hand, are based on a combination of spiritual, psychological, and material means.
Shogar, Ibrahim +4 more
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
The Prescription of Medicinal Cannabis and the Virtue of Prudence: Without Phobia(S) Nor Philia(S)
Acta Médica Portuguesa, 2019 N/a.
Paulo Reis-Pina
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source