Results 21 to 30 of about 11,729 (255)

Hemophilia: a biography on therapeutical approaches

Clinical and Biomedical Research, 2023
The history of hemophilia is ancient, with descriptions dated to the 2nd century AD. The first modern narratives appeared in 1800s, when total blood transfusion was the only available treatment and life expectancy was remarkably low.
Dayenne Catelli, Júlia Plentz Portich, Ebellins Tabares Calvache, Cristiane Seganfredo Weber, Daniel Sander Hoffmann, Guilherme Rasia Bosi, Leo Sekine, Lucia Mariano da Rocha Silla   +7 more
doaj  

Therapeutic approaches for shankopathies [PDF]

Developmental Neurobiology, 2013
ABSTRACTDespite recent advances in understanding the molecular mechanisms of autism spectrum disorders (ASD), the current treatments for these disorders are mostly focused on behavioral and educational approaches. The considerable clinical and molecular heterogeneity of ASD present a significant challenge to the development of an effective treatment ...
Wang, Xiaoming, Bey, Alexandra L, Chung, Leeyup, Krystal, Andrew D, Jiang, Yong‐Hui   +4 more
openaire   +4 more sources

Current status and future challenges of programs for men convicted of gender violence in Spain [PDF]

Psychosocial Intervention, 2013
Programmes involving men convicted of intimate partner violence are subject to a wide range of discussions these days. There are numerous international debates regarding programmes aimed at men convicted of intimate partner violence.
Pablo Carbajosa, Santiago Boira
doaj   +1 more source

Pyogenic Liver Abscess Complicating Acute Cholecystitis: Different Management Options

Medicina, 2022
Acute cholecystitis, which is usually associated with gallstones is one of the most common surgical causes of emergency hospital admission and may be further complicated by mural necrosis, perforation and abscess formation. Perforation of the gallbladder
Daniel Paramythiotis, Anestis Karakatsanis, Eleni Karlafti, Stella Bareka, Elizabeth Psoma, Adam A. Hatzidakis, Antonios Michalopoulos   +6 more
doaj   +1 more source

Ferimentos cervicais: análise retrospectiva de 191 casos

Revista do Colégio Brasileiro de Cirurgiões
OBJETIVOS: Analisar a epidemiologia e a conduta nos ferimentos cervicais. MÉTODO: Foram analisados 487.128 prontuários de pacientes que ingressaram no Serviço de Emergência do Hospital Universitário Cajuru no período de 01/1996 a 06/2001.
Luiz Carlos Von Bahten, João Ricardo Duda, Patrícia Danielle Schultz Zanatta, Andrei Leite de Morais, Fábio Silveira, Márcia Olandoski   +5 more
doaj   +1 more source

The architecture of prions: how understanding would provide new therapeutic insights

Swiss Medical Weekly, 2016
Compelling evidence from the last three decades clearly shows that transmissible spongiform encephalopathies (TSEs) develop as a result of a poorly understood misfolding event that converts the cellular prion protein (PrPC) to an isoform known as PrPSc
Hasier Eraña, Joaquín Castilla
doaj   +1 more source

Social phobia in developmental period: From theory to therapy [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2005
The contemporary integrative theoretical and therapeutic concepts of social phobia in developmental period have been presented in the study. Besides current neurobiological theories, a very important hypothesis about behavioral inhibition has been ...
Kolar Dušan, Bojanin Svetomir
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Systems Biology approaches to cancer: towards new therapeutical strategies and personalized approaches

Molecular & Cellular Oncology, 2019
Network approaches are ubiquitous, from social and ecological systems up to complex biological processes. In our recently published work we used the network framework for a Systems Medicine approach to multiple cancer types, in order to highlight ...
Daniel Remondini
doaj   +1 more source

Computational systems biology in disease modeling and control, review and perspectives

npj Systems Biology and Applications, 2022
Omics-based approaches have become increasingly influential in identifying disease mechanisms and drug responses. Considering that diseases and drug responses are co-expressed and regulated in the relevant omics data interactions, the traditional way of ...
Rongting Yue, Abhishek Dutta
doaj   +1 more source