Results 71 to 80 of about 28,229 (283)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Brain abscess caused by Cladophialophora bantiana: Total remission after full resection and short-course Voriconazole treatment

Medical Mycology Case Reports, 2019
We report on a brain abscess in an immunocompetent man caused by Cladophialophora bantiana, a black mold known to prefer the brain for abscess-formations with a mortality rate up to 65%.
Li-Anne Schweizer, Lorenz Bärlocher, Anne Graber, Katia Boggian   +3 more
doaj   +1 more source

C. elegans fatty acid two-hydroxylase regulates intestinal homeostasis by affecting heptadecenoic acid production [PDF]

, 2018
Background/Aims: The hydroxylation of fatty acids at the C-2 position is the first step of fatty acid α-oxidation and generates sphingolipids containing 2-hydroxy fatty acyl moieties.
Fu, Rong, Huang, Yikai, Li, Yuanbao, Padakanti, Prashanth K., Shi, Xiaoruo, Su, Xiong, Tu, Zhude, Wang, Chunxia, Zhang, Huimin, Zheng, Hanxi, Zhu, Yi   +10 more
core   +3 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Factores influyentes en adherencia al tratamiento en pacientes con riesgo cardiovascular Fatores influentes na aderência ao tratamento em pacientes com risco cardiovascular Influential factors in adherence to treatment in patients with cardiovascular risk

Avances en Enfermería, 2010
Objetivo: describir y analizar los factores que influyen en la adherencia al tratamiento farmacológico y no farmacológico en pacientes con riesgo de enfermedad cardiovascular en la Fundación Cardiovascular de Colombia.
Alba Luz Rodríguez Acelas, Ana Maritza Gómez Ochoa   +1 more
doaj  

Management and efficacy of intensified insulin therapy starting in outpatients [PDF]

, 1989
Diabetic patients under multiple injection insulin therapy (i.e., intensified insulin therapy, IIT) usually start this treatment during hospitalization. We report here on the logistics, efficacy, and safety of IIT, started in outpatients.
A Marble, A Schiffrin, AS Berger, B. Allolio, C Rosak, E Roth, EA Chantelau, FA Capper, FW Whitehouse, G. Ollenschläger, HJ Krönke, KF Hanssen, L Sachs, M Berger, M. Reincke, M. Steffen, P Heinze, RA Rizza, RM Wilson, RR Holman, The DCCT Research Group, V Jörgens, W Spuck, W. Hummerich, W. Winkelmann   +24 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Experiencia en el manejo del paciente con VIH entre médicos de la Secretaría de Salud Experience in HIV patient care among physicians of the National Health Ministry

Salud Pública de México, 1999
OBJETIVO: Conocer la experiencia que los médicos de la Secretaría de Salud (SSA) han obtenido en el manejo del sujeto infectado por el VIH y en el uso de antirretrovirales.
Carlos Magis-Rodríguez, Lilly Esquivel-Pedraza, Carlos López-Martínez   +2 more
doaj  

Equine Musculoskeletal Pathologies: Clinical Approaches and Therapeutical Perspectives—A Review

Veterinary Sciences
Musculoskeletal injuries such as equine osteoarthritis, osteoarticular defects, tendonitis/desmitis, and muscular disorders are prevalent among sport horses, with a fair prognosis for returning to exercise or previous performance levels.
Inês L. Reis, Bruna Lopes, Patrícia Sousa, Ana C. Sousa, Ana R. Caseiro, Carla M. Mendonça, Jorge M. Santos, Luís M. Atayde, Rui D. Alvites, Ana C. Maurício   +9 more
doaj   +1 more source

Successful recovery of COVID-19 pneumonia in a patient from Colombia after receiving chloroquine and clarithromycin

Annals of Clinical Microbiology and Antimicrobials, 2020
Background COVID-19 pandemics is a challenge for public health and infectious diseases clinicians, especially for the therapeutical approach that is not yet adequately defined.
José Millán-Oñate, William Millan, Luis Alfonso Mendoza, Carlos Guillermo Sánchez, Hugo Fernandez-Suarez, D. Katterine Bonilla-Aldana, Alfonso J. Rodríguez-Morales   +6 more
doaj   +1 more source