Deciphering the Relative Contribution of CYP3A4 Versus P-Glycoprotein for the Shared Substrate Cyclosporine-Commentary on Lown et al. [PDF]
Cascorbi I, Kim RB.
europepmc +1 more source
Microphysiological Systems for Comorbidity Studies: Chronic Kidney Disease and Osteoarthritis
This review highlights the potential of organ‐on‐a‐chip systems for studying comorbidities, using chronic kidney disease (CKD) and osteoarthritis (OA) as examples. It summarizes recent advances in kidney‐on‐a‐chip and joint‐on‐a‐chip models and discusses their current and potential application in investigating CKD, OA, and CKD‐OA comorbidity, aiming to
Mingying Han+7 more
wiley +1 more source
Clinical pharmacology and therapeutics in the 1980s [editorial] [PDF]
C. T. Dollery
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Correction for: EpiAge: a next-generation sequencing-based <i>ELOVL2</i> epigenetic clock for biological age assessment in saliva and blood across health and disease. [PDF]
Cheishvili D+5 more
europepmc +1 more source
Animal‐Free Setup of a 3D Mature Adipocyte‐Macrophage Co‐Culture to Induce Inflammation In Vitro
A completely animal‐free 3D co‐culture is developed using human fat cells and immune cells. Animal‐based materials are replaced with gellan gum hydrogel and a serum‐free medium. Immune cells are effectively activated, producing specific inflammatory signals.
Sophia Nowakowski+3 more
wiley +1 more source
Ronald Kibuuka,1 Ferestas Mpasa,2 Andrew Marvin Kanyike,1 Chizoma Millicent Ndikom,3 Atipatsa Chiwanda Kaminga,2 Samuel Owusu-Sekyere,4 Adenike Ogah,5 Abigail Kusi Amponsah,6 Kennedy Kiyimba,1 Samuel Baker Obakiro,1 Getrude Munthali,2 Wanangwa Kenneth ...
Kibuuka R+16 more
doaj
Leading the Way: Multi-Drug Resistance Protein (MDR1) and Clinical Pharmacology-Commentary on Kim et al. [PDF]
Giacomini KM.
europepmc +1 more source
Permeation Enhancer‐based Ionogel Shows Remarkable Potential for Oral Insulin Delivery
This study proposes a novel formulation of decanoate in an ionic liquid inspired drug delivery system. The formulation demonstrates ideal physicochemical and material properties for oral peptide delivery. Findings indicate that choline decanoate (1:2 molar ratio) forms a viscoelastic gel that enables high oral bioavailability of insulin in rats ...
Konstantinos Raptis+6 more
wiley +1 more source
Introducing Digital Pharmacometrics: A Pharmacokinetics (PK)/Pharmacodynamics (PD) Framework for Prescription Digital Therapeutics. [PDF]
Lakhan SE.
europepmc +1 more source
Clinical Pharmacology and Therapeutics Series. Vol. 3. Anti-Rheumatic Drugs [PDF]
J. T. Scott
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