Results 201 to 210 of about 1,549,234 (325)

MXene/PEDOT Functional Coatings on Flexible Microelectrode Arrays for Multianalyte In Vivo Neurochemical Sensing and Electrophysiology

Advanced Functional Materials, EarlyView.
A MXene/PEDOT coating enables multimodal functionality and dual‐analyte detection of dopamine and serotonin in flexible microelectrode arrays while enhancing electrophysiological recording quality. The anti‐fouling, low‐impedance interface overcomes key limitations of conventional coatings, providing a robust and versatile platform to investigate the ...
Ilaria Gatti, Karamullah Eisawi, Umisha Siwakoti, Greyson Jadwin, Ashmita Sigdel, Michela Chiappalone, Deepak Kumbhare, Michael Naguib, Elisa Castagnola   +8 more
wiley   +1 more source

Corrigendum to: "Astrocytic glutamate transporter 1 (GLT1) deficient mice exhibit repetitive behaviors" [Behav. Brain Res. 396 (2021) 112906]. [PDF]

Behav Brain Res
Jia YF, Wininger K, Peyton L, Ho AM, Choi DS.   +4 more
europepmc   +1 more source

Coagulative Granular Hydrogels with an Enzyme Catalyzed Fibrin Network for Endogenous Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
Coagulative granular hydrogels are composed of packed thrombin‐functionalized microgels that catalyze the conversion of fibrinogen into a secondary fibrin network, filling the interstitial voids. This bio‐inspired approach stabilizes the biomaterial to match the robustness of bulk hydrogels without compromising injectability, mimicking the initial ...
Zhipeng Deng, Camila B. Tovani, Simona Bianco, Gianni Comandini, Aya Elghajiji, Mina Aleemardani, Roxana Moscalu, Jeremie Zappia, Bianca Fernandes, Olivia Annett, Chrissy L. Hammond, Jason Wong, Dave J. Adams, Fabrizio Scarpa, Michael R. Whitehouse, Annela M. Seddon, James P. K. Armstrong   +16 more
wiley   +1 more source

Clinical Pharmacology Quality Assurance Program for Global HIV and Co-Infection Drug Development. [PDF]

Clin Pharmacol Ther
DiFrancesco R, Wood TD, Cha R, Hochreiter JS, Rosenkranz SL, Farhad M, Whitson KR, Gould CE, Hill LE, Hale LL, Lindhorst PH, Ghazal D, Taylor CR, Quraishi M, Siminski SM, Cramer Y, Sprenger HL, Morse GD.   +17 more
europepmc   +1 more source

Mechanical and Electrical Phenotype of hiPSC‐Cardiomyocytes on Fibronectin‐Based Hydrogels

Advanced Healthcare Materials, EarlyView.
We introduce fibronectin‐based PEG hydrogels with controlled rigidity to enable the culture of iPSC‐derived cardiomyocytes. These substrates offer an alternative to the current culture of these cells on fibronectin‐coated glass, providing enhanced structural and functional behavior. The system provides a more physiologically relevant platform to assess
Ana Da Silva Costa, Lineta Stonkute, Sara Trujillo, Mariana Azevedo Gonzalez Oliva, Francis Burton, Matthew J. Dalby, Oana Dobre, Godfrey Smith, Manuel Salmeron‐Sanchez   +8 more
wiley   +1 more source

Obstetric Pharmacology at an Inflection Point. [PDF]

J Clin Pharmacol
Eke AC.
europepmc   +1 more source

Comparative Efficacy, Safety, and Cost-Utility of DPP-4 Inhibitors and Metformin Combination Therapy in Type 2 Diabetes: A Systematic Review of Real-World Clinical and Economic Outcomes

Journal of Diabetes Research
Abdulgafar Olayiwola Jimoh, Shuaibu Abdullahi Hudu, Anas Ahmad Sabir, Adamu Ahmed Adamu, Nura Bello, Albashir Tahir, Nura Abubakar   +6 more
doaj   +1 more source

Pharmacomicrobiomics: The Impact of Human Microbiome Variations on Systems Pharmacology and Personalized Therapeutics

Omics, 2014
M. ElRakaiby, B. Dutilh, Mariam R. Rizkallah, A. Boleij, J. Cole, R. Aziz   +5 more
semanticscholar   +1 more source

Lysosome‐Acidifying Nanoparticles Rescue A30P α‐Synuclein Induced Neuronal Death in Cellular and Drosophila Models of Parkinson's Disease

Advanced Healthcare Materials, EarlyView.
Lysosome‐targeted acidic nanoparticles based on a biodegradable poly(ethylene tetrafluorosuccinate‐co‐succinate) copolymer are engineered to restore impaired lysosomal acidification through pH‐responsive intracellular degradation. Localized acid release enhances autophagic proteolysis, reduces α‐synuclein accumulation, and preserves dopaminergic neuron
Chih Hung Lo, Mengda Ren, Gavin Wen Zhao Loi, Eka Norfaishanty Saipuljumri, Jonathan Indajang, Kah Leong Lim, Jialiu Zeng   +6 more
wiley   +1 more source

Genipin‐Crosslinked, Silane‐Anchored 3D Tumor–Stroma Microtissues for High‐Content On‐Chip Drug Testing

Advanced Healthcare Materials, EarlyView.
We describe a microfluidic tumor‐stroma co‐culture model, engineered to resist collagen‐hydrogel contraction driven by fibroblast activity. Surface silanization with APTES covalently anchors the matrix to the chip, while Genipin crosslinking progressively increases stiffness and elasticity without harming cells. This supports >10 days of co‐culture and
Doriane Le Manach, Reza Kowsari‐Esfahan, Emilia Reszczyńska, Philippe Nghe, Matthias Nees   +4 more
wiley   +1 more source