Results 21 to 30 of about 9,958 (268)
Advanced Science, EarlyView.Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann +26 more
wiley +1 more source
Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease
Advanced Science, EarlyView.ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan +17 more
wiley +1 more source
Ketamine in the Treatment of Depression
Journal of Education, Health and SportIntroduction Depression is one of the most common mental illnesses. Over the course of a lifetime, several percent of the adult population suffers from depression. There are many treatments for depression like pharmacotherapy and psychotherapy.
Urszula Agnieszka Kaczmarska +9 more
doaj +1 more source
Advanced Science, EarlyView.Using a novel zebrafish‐based inflammatory screening strategy, we screened and identified 18β‐glycyrrhetinic acid (18β‐GA) as a promising anti‐inflammatory candidate. We uncover a microglial mTOR–autophagy–NLRP3 axis that constitutes the mechanistic core of 18β‐GA–mediated neuroprotection.
Hua Gan +11 more
wiley +1 more source
American Journal of Industrial Medicine, EarlyView.ABSTRACT Hypersensitivity pneumonitis (HP) is an immune‐mediated interstitial lung disease triggered by repeated inhalation of organic or chemical antigens. Occupational exposures account for approximately 19% of all cases. Early diagnosis, identification of the responsible antigen(s), and immediate avoidance of exposure are crucial to prevent ...
Ludwig Frei‐Stuber +6 more
wiley +1 more source
Romanian Journal of Physical TherapyIntroduction: In the functional recovery after total hip arthroplasty, a very important role is played by the rehabilitation of deficient muscle strength, with the femoral quadriceps being one of the muscles that atrophies most rapidly.
Calin VUTAN +5 more
doaj +1 more source
Do childhood trauma and attachment dimensions predict psychotic-like experiences in a non-clinical sample? [PDF]
Klinik Psikoloji Dergisi, 2020 Psychotic-like experiences (PLEs) are very common in the healthy population of society and can be seen without being clinically diagnosed. Many studies have emphasized the relationship between PLEs and childhood trauma or attachment dimensions.
Feyzan Ustamehmetoğlu, Oya Mortan Sevi
doaj +1 more source
Australian Journal of Social Issues, EarlyView.ABSTRACT In this paper, we trace the journey to create the Strong Roots for our Futures Program, a government program to resource and support Traditional Owners to undertake a range of activities in areas where no state recognition existed. We provide a background to state recognition in Victoria before considering the program design, leading to an ...
Nell Reidy +2 more
wiley +1 more source
Axio-Onto-Epistemology in Systemic Practice
MurmurationsThis paper explores the inter/intra-connectedness of axiology, ontology, and epistemology as lived experiences. It emphasises their profound impact on academic inquiry, practice and everyday human existence.
Peace Anumah
doaj +1 more source
Anatomical Sciences Education, EarlyView.Abstract The study of neuroanatomy is fundamental in many scientific fields. Despite this, it is a challenging subject for students. As technology evolves, it is being increasingly incorporated into educational methods, including the teaching of neuroanatomy. Three‐dimensional (3D) visualizations are well suited for displaying neuroanatomy.
Merlin J. Fair +5 more
wiley +1 more source