Results 221 to 230 of about 1,594,004 (375)

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

Molecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova, Marketa Pavlikova, Lucie Pifkova, Robin Jugas, Tana Machackova, Lenka Radova, Milana Sachlova, Renata Bartosova, Tetiana Samoilenko, Zuzana Feckova, Jana Orlickova, Erika Slamova, Elleni Ponechal Michu, Dagmar Al Tukmachi, Michaela Ruckova, Martina Vodinska, Jan Kotoucek, Tina Catela Ivkovic, Marie Boudna, Lucia Bohovicova, Teodor Stanek, Jana Halamkova, Martin Svoboda, Vladimir Prochazka, Tomas Grolich, Zdenek Kala, Ondrej Slaby   +26 more
wiley   +1 more source

Software-Enhanced Drugs™: The third platform reshaping drug development. [PDF]

Proc Natl Acad Sci U S A
Lakhan SE, Wicks P.
europepmc   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Correction: The potential role of major dissection observed on optical frequency-domain imaging in optimal lumen expansion after coronary intravascular lithotripsy: a comparative analysis with calcium fractures. [PDF]

Cardiovasc Interv Ther
Miyata K, Asano T, Suzuki T, Ono M, Aoki J.   +4 more
europepmc   +1 more source

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Textbook of Pharmacology and Therapeutics

, 1934
NULL AUTHOR_ID
openalex   +1 more source

EPIGENETIC PROFILING AND THERAPEUTICS IN LIVER DISEASE [PDF]

, 2019
Marco Giammanco, Rosaria Maria Pipitone, Rossella Zito, Stefania Grimaudo   +3 more
core  

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

SECTION OF PHARMACOLOGY AND THERAPEUTICS [PDF]

, 1937

openalex   +1 more source

Immunoprofiling at an Institutional Scale Reveals That High Numbers of Intratumoral CD8⁺ and PD-1⁺ Cells Predict Superior Patient Survival Across Major Cancer Types Independent of Major Risk Factors. [PDF]

JCO Precis Oncol
Alessi JV, Lindsay JR, Giobbie-Hurder A, Sharma B, Felt K, Kumari P, Mazor T, Cerami E, Lotter W, Altreuter J, Weirather J, Dryg I, Hoebel K, Manos M, Adib E, Curtis JD, Ricciuti B, Di Federico A, Ghandour F, Saad E, Wang XA, Pecci F, Holovatska M, Gandhi MM, Hughes ME, O'Meara TA, Chan SJ, Pfaff K, Konstantinopoulos PA, Hodi FS, Shipp MA, Signoretti S, Choueiri T, Wei XX, Santagata S, Hanna GJ, Lin NU, Tolaney SM, Liu J, Sorger PK, Lindeman N, Sholl LM, Nowak JA, Barbie D, Awad MM, Johnson BE, Rodig SJ.   +46 more
europepmc   +1 more source