Results 1 to 10 of about 7,903,864 (271)
Angiogenic signaling pathways and anti-angiogenic therapy for cancer
Signal Transduction and Targeted Therapy, 2023 Angiogenesis, the formation of new blood vessels, is a complex and dynamic process regulated by various pro- and anti-angiogenic molecules, which plays a crucial role in tumor growth, invasion, and metastasis.
Zhenling Liu +4 more
semanticscholar +1 more source
Neoantigens: promising targets for cancer therapy
Signal Transduction and Targeted Therapy, 2023 Recent advances in neoantigen research have accelerated the development and regulatory approval of tumor immunotherapies, including cancer vaccines, adoptive cell therapy and antibody-based therapies, especially for solid tumors.
N-N Xie +5 more
semanticscholar +1 more source
Smart nanoparticles for cancer therapy
Signal Transduction and Targeted Therapy, 2023 Smart nanoparticles, which can respond to biological cues or be guided by them, are emerging as a promising drug delivery platform for precise cancer treatment.
Leming Sun +8 more
semanticscholar +1 more source
Targeting p53 pathways: mechanisms, structures and advances in therapy
Signal Transduction and Targeted Therapy, 2023 The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has been a major focus of oncology research. The p53 protein is a transcription factor that can activate the expression of multiple target genes and plays critical roles ...
Haolan Wang +3 more
semanticscholar +1 more source
Targeting integrin pathways: mechanisms and advances in therapy
Signal Transduction and Targeted Therapy, 2023 Integrins are considered the main cell-adhesion transmembrane receptors that play multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in biochemical and mechanical signals between cells and their environment in a wide ...
Xiaocong Pang +9 more
semanticscholar +1 more source
Endovascular therapy for ischemic stroke with perfusion-imaging selection.
New England Journal of Medicine, 2015 BACKGROUND Trials of endovascular therapy for ischemic stroke have produced variable results. We conducted this study to test whether more advanced imaging selection, recently developed devices, and earlier intervention improve outcomes.
B. Campbell +35 more
semanticscholar +1 more source
In Silico Implementation of Evolutionary Paradigm in Therapy Design: Towards Anti-Cancer Therapy as Darwinian Process [PDF]
Journal of Theoretical Biology 485(2020) 110038, 2018 In here presented in silico study we suggest a way how to implement the evolutionary principles into anti-cancer therapy design. We hypothesize that instead of its ongoing supervised adaptation, the therapy may be constructed as a self-sustaining evolutionary process in a dynamic fitness landscape established implicitly by evolving cancer cells ...
arxiv +1 more source
Nanomedicine in cancer therapy
Signal Transduction and Targeted Therapy, 2023 Cancer remains a highly lethal disease in the world. Currently, either conventional cancer therapies or modern immunotherapies are non-tumor-targeted therapeutic approaches that cannot accurately distinguish malignant cells from healthy ones, giving rise
Dahua Fan +5 more
semanticscholar +1 more source
Engineered exosomes from different sources for cancer-targeted therapy
Signal Transduction and Targeted Therapy, 2023 Exosome is a subgroup of extracellular vesicles, which has been serving as an efficient therapeutic tool for various diseases. Engineered exosomes are the sort of exosomes modified with surface decoration and internal therapeutic molecules.
Menghui Zhang +7 more
semanticscholar +1 more source
Incubation periods under various anti-retroviral therapies in homogeneous mixing and age-structured dynamical models: A theoretical approach [PDF]
Rocky Mountain Journal of Mathematics, (2015), 45, 3: 973-1031, 2006 With the launch of second line anti-retroviral therapy for HIV infected individuals, there has been an increased expectation on surviving period of people with HIV. We consider previously well-known models in HIV epidemiology where the parameter for incubation period is used as one of the important components to explain the dynamics of the variables ...
arxiv +1 more source