Results 121 to 130 of about 385,973 (351)

Computer-Assisted Delivery of Cognitive-Behavioral Therapy: Efficacy and durability of CBT4CBT among cocaine-dependent individuals maintained on methadone

American Journal of Psychiatry, 2014
Objectives A previous pilot trial evaluating computer-based cognitive behavioral therapy (CBT4CBT) among 77 heterogeneous substance users (alcohol, marijuana, cocaine, opioids) provided preliminary support for its efficacy in the context of a community ...
K. Carroll, Brian D. Kiluk, C. Nich, Melissa A. Gordon, Galina A. Portnoy, Daniel Marino, S. Ball   +6 more
semanticscholar   +1 more source

Unsupervised risk factor identification across cancer types and data modalities via explainable artificial intelligence

npj Digital Medicine
Risk stratification is an important tool in clinical decision-making, yet current approaches often fail to translate sophisticated survival analysis into actionable clinical criteria. We present a novel method for training any neural network architecture
Maximilian Ferle, Jonas Ader, Thomas Wiemers, Nora Grieb, Beatrice Berneck, Adrian Lindenmeyer, Hartmut Goldschmidt, Elias K. Mai, Uta Bertsch, Hans-Jonas Meyer, Thomas Neumuth, Markus Kreuz, Kristin Reiche, Maximilian Merz   +13 more
doaj   +1 more source

SPEECH THERAPY ASSISTANCE TO CHILDREN OF MIDDLE PRESCHOOL AGE BY MEANS OF COMPUTER DIDACTIC GAMES

Інформаційні технології і засоби навчання
The article highlights the peculiarities of speech therapy assistance to children of middle preschool age using computer didactic games. All the children who were assisted had generalized underdevelopment of speech (GUS).
Viktor Hladush, Liudmyla Kotlova, Natalija Krasikova, Nadija Pavlyk   +3 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

A pilot study exploring quality of life experienced by patients undergoing negative pressure wound therapy as part of their wound care treatment compared to patients receiving standard wound care

, 2014
The use of Negative Pressure Wound Therapy (NPWT) has been widely documented as a technique to help heal complex wounds. This paper presents the findings of a preliminary study which aimed to explore quality of life experienced by patients undergoing ...
Gillibrand, Warren, Stephenson, John, Milne, Jeanette, Gillibrand, Warren P., Cook, Leanne, Ousey, Karen J., Ousey, Karen   +6 more
core   +1 more source

Fluorescence-Guided Surgery in Head and Neck Squamous Cell Carcinoma (HNSCC)

International Journal of Translational Medicine
Head and neck squamous cell carcinomas (HNSCCs) are the seventh most common form of cancer worldwide, typically characterized by high mortality and significant morbidity, including pain and speech and swallowing disorders. Complete tumor tissue resection,
Albrecht Blosse, Markus Pirlich, Andreas Dietz, Christin Möser, Katrin Arnold, Jessica Freitag, Thomas Neumuth, David M. Smith, Hans Kubitschke, Maximilian Gaenzle   +9 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

The biomechanics of negative-pressure wound therapy

, 2011
Includes references.Despite the success of negative-pressure wound therapy, its mechanism of action remains unclear. The common perception that it reduces tissue pressure and increases perfusion has recently been challenged following the observation that
Kairinos, Nicolas
core  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Factors associated with suboptimal adherence to antiretroviral therapy in Viet Nam: a cross-sectional study using audio computer-assisted self-interview (ACASI)

BMC Infectious Diseases, 2013
BackgroundOptimal adherence to antiretroviral therapy (ART) is necessary for people living with HIV/AIDS (PLHIV). There have been relatively few systematic analyses of factors that promote or inhibit adherence to antiretroviral therapy among PLHIV in ...
H. M. Do, M. Dunne, Masaya Kato, C. Pham, K. Nguyen   +4 more
semanticscholar   +1 more source