Results 171 to 180 of about 8,614,247 (315)

Cumulative corticosteroid burden over 25 years in patients initiating biologic therapy for severe asthma: a nationwide cohort study. [PDF]

ERJ Open Res
Berner G, Soendergaard MB, Hansen S, Bjerrum AS, von Bülow A, Hilberg O, Bonnesen B, Johnsen CR, Johansson SL, Rasmussen LM, Schmid JM, Ulrik CS, Porsbjerg C, Håkansson KEJ.   +13 more
europepmc   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Neoadjuvant transarterial chemoembolization with tyrosine kinase and immune checkpoint inhibitors improves survival from resectable hepatocellular carcinoma in a multicenter, retrospective study (GUIDANCE002). [PDF]

Commun Med (Lond)
Yang DL, Qin C, Peng N, Liu SP, Yu YQ, Nong JL, Zeng FJ, Su Z, Yang YY, Yang FQ, Li MJ, Wu MS, Wang XY, Liang YR, Li FX, Chen SC, Lai YC, Pang QQ, Zhong TM, Yan YH, Zhang YY, Ye L, Dong XF, Li WF, Liu J, Yao HB, Wu PS, Mao XS, Ou JJ, Chen YZ, Wang GD, Chen K, Deng ZJ, Su JY, Qiu GG, Liu ZD, Wang JM, Zhang Y, Liang XM, Xiang BD, Ma L, Zhong JH, GUIDANCE investigators.   +42 more
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Retracted: Application of Ontology Matching Algorithm Based on Linguistic Features in English Pronunciation Quality Evaluation

Occupational Therapy International, 2023
Occupational Therapy International
doaj   +1 more source

An analysis of attitudes toward gene therapy in people with severe hemophilia in Germany, a survey-based cross-sectional study. [PDF]

Ther Adv Hematol
Babayeva S, Peyvandi A, Schepperle C, Auerswald G, Rauchfuss S, Peyvandi F, Cutica I, Miesbach W.   +7 more
europepmc   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Successful Dichoptic Therapy for Amblyopia in a Child Unable to Tolerate Occlusion Therapy due to Autism Spectrum Disorder. [PDF]

Case Rep Ophthalmol Med
Nakatsuka S, Iwata Y, Ito H, Nakano Y, Mokuno K, Handa T.   +5 more
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Early hypocortisolism with persistent remission following osilodrostat in a patient with long-standing Cushing disease. [PDF]

JCEM Case Rep
Sasson L, Shimon I.
europepmc   +1 more source