Results 11 to 20 of about 7,903,864 (271)
Applications of Artificial Intelligence in Particle Radiotherapy [PDF]
arXiv, 2021 Radiotherapy, due to its technology-intensive nature and reliance on digital data and human-machine interactions, is particularly suited to benefit from artificial intelligence (AI) to improve the accuracy and efficiency of its clinical workflow. Recently, various artificial intelligence (AI) methods have been successfully developed to exploit the ...
arxiv
Computational model for tumor response to adoptive cell transfer therapy [PDF]
arXiv, 2022 One of the barriers to the development of effective adoptive cell transfer therapies (ACT), specifically for genetically engineered T-cell receptors (TCRs), and chimeric antigen receptor (CAR) T-cells, is target antigen heterogeneity. It is thought that intratumor heterogeneity is one of the leading determinants of therapeutic resistance and treatment ...
arxiv
Targeting cancer stem cell pathways for cancer therapy
Signal Transduction and Targeted Therapy, 2020 Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been considered promising therapeutic targets for cancer therapy. These cells have self-renewal capacity and differentiation potential and contribute to multiple tumor ...
Liqun Yang +10 more
semanticscholar +1 more source
Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock
, 2001 Background Goal-directed therapy has been used for severe sepsis and septic shock in the intensive care unit. This approach involves adjustments of cardiac preload, afterload, and contractility to balance oxygen delivery with oxygen demand.
Manuel +15 more
semanticscholar +1 more source
Antibody drug conjugate: the “biological missile” for targeted cancer therapy
Signal Transduction and Targeted Therapy, 2022 Antibody–drug conjugate (ADC) is typically composed of a monoclonal antibody (mAbs) covalently attached to a cytotoxic drug via a chemical linker. It combines both the advantages of highly specific targeting ability and highly potent killing effect to ...
Zhiwen Fu +4 more
semanticscholar +1 more source
Publisher Correction to: Renal Replacement Therapy, volume 5
Renal Replacement Therapy, 2019 An error occurred during the publication of a number of articles in Renal Replacement Therapy. Several articles were published in volume 5 with a duplicate citation number.
Renal Replacement Therapy
doaj +1 more source
Challenges in constructing genetic instruments for pharmacologic therapies [PDF]
arXiv, 2020 The genes that encode the targets of most therapies do not have rare variants with large-effect or common variants with moderate effects on the biomarker reflecting the pharmacologic action of the corresponding therapy. Therefore, providing genetic target validation for most therapies is challenging.
arxiv
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Therapy Control and Patient Safety for Proton Therapy [PDF]
CERN Yellow Report CERN-2017-004-SP pp. 309-319, 2018 This contribution describes general concepts for control and safety systems in proton therapy. These concepts are illustrated by concrete examples implemented in the Proscan facility at PSI.
arxiv +1 more source
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source