Results 231 to 240 of about 8,614,247 (315)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Timing and Intensity of Rehabilitation Services During Acute Stroke Hospitalization: Impacts on Functional Recovery and Community Discharge. [PDF]

Am J Occup Ther
Edelstein J, Hoffman A, Luby DM, Rosenthal J, Graham JE.   +4 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Real-world Treatment Selection and Shared Decision-making in De Novo Metastatic Castration-sensitive Prostate Cancer in Japan. [PDF]

Cancer Diagn Progn
Furubayashi N, Tsujita J, Takayama A, Shiraishi Y, Nakamura M, Negishi T.   +5 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Efficacy of NAs in combination with Peg-IFN for functional cure in patients with CHB: a meta-analysis of RCTs. [PDF]

Ann Med
Zhang Y, Zhang Z, Li X, Cao W, Wang S, Deng W, Wei X, Yao L, Xie Y, Li M.   +9 more
europepmc   +1 more source

MajesTEC-3: Redefining what's possible in multiple myeloma. [PDF]

Clin Hematol Int
Al Hadidi S, Gaballa M.
europepmc   +1 more source

Oropharyngeal Dysphagia in Parkinson's Disease: An Analysis of Prevalence, Swallow Therapy Utilization, and Complication Rates. [PDF]

Laryngoscope Investig Otolaryngol
Liu V, Wehbi N, Sai P, Cazzato K, Yip H.
europepmc   +1 more source

Use of Solution-Focused Brief Therapy Within Adult Community Mental Health: A Scoping Review. [PDF]

Clin Psychol Psychother
Orr M, Ryder S, Considine J.
europepmc   +1 more source

Retracted: Work Emotion Intervention and Guidance Training Method for Enterprise Employees Based on Virtual Reality

Occupational Therapy International
Occupational Therapy International
doaj   +1 more source