Imperial strategy of cancer cells through mitochondrial transfer
Cangkrama et al. demonstrated that cancer cells donate their mitochondria to fibroblasts through mitochondrial transfer, reprogramming them into ‘MitoCAF’. Likewise, our group has identified mitochondrial transfer from cancer cells to tumor infiltrating lymphocytes, resulting in mitochondrial ‘hijack’ and impaired antitumor immunity.
Takamasa Ishino, Yosuke Togashi
wiley +1 more source
Clinical significance on switching CDK4/6 inhibitors among 13,284 patients with metastatic breast cancer. [PDF]
Nishina T +6 more
europepmc +1 more source
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Impact of antithrombotic therapy on colonoscopy outcomes in FIT-positive patients: implications for polyp detection, diverticulosis and normal findings. [PDF]
Abu-Freha N +4 more
europepmc +1 more source
Advances in cancer therapy: clinical benefit of new cancer drugs
Daniel Tobias Michaeli +2 more
openalex +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Efficacy and safety of proton therapy and photon therapy for patients with craniopharyngioma: a systematic review and meta‑analysis. [PDF]
Pan LS +5 more
europepmc +1 more source
RAS‐targeted therapies have become a clinical reality. Although promising results in patients have been achieved, there are still challenges ahead such as coping with drug resistance. Here we summarize selected RAS inhibitors targeting either individual KRAS mutant isoforms (KRASG12C, KRASG12D, KRASG12V) or exhibiting a wider inhibitory spectrum ...
Matthias Drosten, Mariano Barbacid
wiley +1 more source
Investigating a Telerehabilitation Platform Integrated With a Rehabilitation Robot Using Microsoft HoloLens 2 for Upper-Limb Therapy: Pilot Usability Study. [PDF]
Khan MMR +4 more
europepmc +1 more source

