Results 21 to 30 of about 6,441,268 (293)
Targeting p53 pathways: mechanisms, structures and advances in therapy
Signal Transduction and Targeted Therapy, 2023 The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has been a major focus of oncology research. The p53 protein is a transcription factor that can activate the expression of multiple target genes and plays critical roles ...
Haolan Wang +3 more
semanticscholar +1 more source
Engineered exosomes from different sources for cancer-targeted therapy
Signal Transduction and Targeted Therapy, 2023 Exosome is a subgroup of extracellular vesicles, which has been serving as an efficient therapeutic tool for various diseases. Engineered exosomes are the sort of exosomes modified with surface decoration and internal therapeutic molecules.
Menghui Zhang +7 more
semanticscholar +1 more source
Nanomedicine in cancer therapy
Signal Transduction and Targeted Therapy, 2023 Cancer remains a highly lethal disease in the world. Currently, either conventional cancer therapies or modern immunotherapies are non-tumor-targeted therapeutic approaches that cannot accurately distinguish malignant cells from healthy ones, giving rise
Dahua Fan +5 more
semanticscholar +1 more source
Antibody drug conjugate: the “biological missile” for targeted cancer therapy
Signal Transduction and Targeted Therapy, 2022 Antibody–drug conjugate (ADC) is typically composed of a monoclonal antibody (mAbs) covalently attached to a cytotoxic drug via a chemical linker. It combines both the advantages of highly specific targeting ability and highly potent killing effect to ...
Zhiwen Fu +4 more
semanticscholar +1 more source
TREATMENTCINE THERAPY THERAPY CAOFCLEAICARBUNCLE [PDF]
Journal of the American Medical Association, 1911 The brilliant results produced by the use of Staphylococcus aureus vaccine in the treatment of carbuncles is already to well known to require further discussion. The following case, however, I am sure, is of sufficient interest to warrant reporting: History. —Mr. R., aged 48, had been suffering with diabetes for three years, during which time he had
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Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock
, 2001 Background Goal-directed therapy has been used for severe sepsis and septic shock in the intensive care unit. This approach involves adjustments of cardiac preload, afterload, and contractility to balance oxygen delivery with oxygen demand.
Manuel +15 more
semanticscholar +1 more source
Targeting cancer stem cell pathways for cancer therapy
Signal Transduction and Targeted Therapy, 2020 Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been considered promising therapeutic targets for cancer therapy. These cells have self-renewal capacity and differentiation potential and contribute to multiple tumor ...
Liqun Yang +10 more
semanticscholar +1 more source
Therapy for psychiatric therapy [PDF]
British Journal of General Practice, 2009 The September themed issue of the BJGP leads with Professor Dowrick saying the mainstays of GPs management are prescription of medication and referral for psychological therapy.1 Having trained in the 1980s we were taught our …
openaire +2 more sources