Results 21 to 30 of about 7,903,864 (271)

Deterministic and Stochastic in-host Tuberculosis Models for Bacterium-directed and Host-directed Therapy Combination [PDF]

arXiv, 2021
Mycobacterium tuberculosis infection can involve all immune system components and can result in different disease outcomes. The antibiotic TB drugs require strict adherence to prevent both disease relapse and mutation of drug- and multidrug-resistant strains.
arxiv  

Adeno-associated virus as a delivery vector for gene therapy of human diseases

Signal Transduction and Targeted Therapy
Adeno-associated virus (AAV) has emerged as a pivotal delivery tool in clinical gene therapy owing to its minimal pathogenicity and ability to establish long-term gene expression in different tissues.
Jiang-Hui Wang, Dominic J Gessler, Wei Zhan, Thomas Gallagher, Guangping Gao   +4 more
semanticscholar   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

KSoF: The Kassel State of Fluency Dataset -- A Therapy Centered Dataset of Stuttering [PDF]

arXiv, 2022
Stuttering is a complex speech disorder that negatively affects an individual's ability to communicate effectively. Persons who stutter (PWS) often suffer considerably under the condition and seek help through therapy. Fluency shaping is a therapy approach where PWSs learn to modify their speech to help them to overcome their stutter.
arxiv  

Extracellular vesicles as tools and targets in therapy for diseases

Signal Transduction and Targeted Therapy
Extracellular vesicles (EVs) are nano-sized, membranous structures secreted into the extracellular space. They exhibit diverse sizes, contents, and surface markers and are ubiquitously released from cells under normal and pathological conditions.
M. A. Kumar, S. K. Baba, Hana Q. Sadida, Sara Al Marzooqi, J. Jerobin, Faisal H. Altemani, Naseh A Algehainy, Mohammad A Alanazi, Abdul-Badi Abou-Samra, Rakesh Kumar, AMMIRA-SARAH AL-SHABEEB AKIL, M. Macha, Rashid Mir, Ajaz A. Bhat   +13 more
semanticscholar   +1 more source

Comprehensive review of targeted therapy for colorectal cancer

Signal Transduction and Targeted Therapy, 2020
Colorectal cancer (CRC) is among the most lethal and prevalent malignancies in the world and was responsible for nearly 881,000 cancer-related deaths in 2018. Surgery and chemotherapy have long been the first choices for cancer patients.
Yuanhong Xie, Yingxuan Chen, J. Fang
semanticscholar   +1 more source

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, Volume 599, Issue 10, Page 1468-1480, May 2025.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

Mitochondrial dysfunction: mechanisms and advances in therapy

Signal Transduction and Targeted Therapy
Mitochondria, with their intricate networks of functions and information processing, are pivotal in both health regulation and disease progression.
Yao Zong, Hao Li, Peng Liao, Long Chen, Yao Pan, Yongqiang Zheng, Changqing Zhang, De-chen Liu, Minghao Zheng, Junjie Gao   +9 more
semanticscholar   +1 more source

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

FEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi   +6 more
wiley   +1 more source

Macrophages as tools and targets in cancer therapy

Nature reviews. Drug discovery, 2022
Tumour-associated macrophages are an essential component of the tumour microenvironment and have a role in the orchestration of angiogenesis, extracellular matrix remodelling, cancer cell proliferation, metastasis and immunosuppression, as well as in ...
A. Mantovani, P. Allavena, F. Marchesi, C. Garlanda   +3 more
semanticscholar   +1 more source