Results 31 to 40 of about 6,441,268 (293)

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

NF-κB in biology and targeted therapy: new insights and translational implications

Signal Transduction and Targeted Therapy
NF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was identified as a pivotal pathway in mediating inflammatory responses.
Qing Guo, Yizi Jin, Xinyu Chen, Xiaomin Ye, Xin Shen, Mingxi Lin, C. Zeng, Teng Zhou, Jian Zhang   +8 more
semanticscholar   +1 more source

Therapie [PDF]

Archiv für Dermatologie und Syphilis, 1903
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Krefting,, Oppenheimer, E.-D., Neisser, Paul, Klotz, H. G., Joseph, Max, Spietschka,, Prißmann, S.   +6 more
openaire   +2 more sources

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Adeno-associated virus as a delivery vector for gene therapy of human diseases

Signal Transduction and Targeted Therapy
Adeno-associated virus (AAV) has emerged as a pivotal delivery tool in clinical gene therapy owing to its minimal pathogenicity and ability to establish long-term gene expression in different tissues.
Jiang-Hui Wang, Dominic J Gessler, Wei Zhan, Thomas Gallagher, Guangping Gao   +4 more
semanticscholar   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Extracellular vesicles as tools and targets in therapy for diseases

Signal Transduction and Targeted Therapy
Extracellular vesicles (EVs) are nano-sized, membranous structures secreted into the extracellular space. They exhibit diverse sizes, contents, and surface markers and are ubiquitously released from cells under normal and pathological conditions.
Mudasir A Kumar, S. K. Baba, Hana Q. Sadida, Sara Al Marzooqi, J. Jerobin, Faisal H. Altemani, Naseh A Algehainy, Mohammad A Alanazi, Abdul-Badi Abou-Samra, Rakesh Kumar, AMMIRA-SARAH AL-SHABEEB AKIL, M. Macha, Rashid Mir, Ajaz A. Bhat   +13 more
semanticscholar   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Mitochondrial dysfunction: mechanisms and advances in therapy

Signal Transduction and Targeted Therapy
Mitochondria, with their intricate networks of functions and information processing, are pivotal in both health regulation and disease progression.
Yao Zong, Hao Li, Peng Liao, Long Chen, Yao Pan, Yongqiang Zheng, Changqing Zhang, De-chen Liu, Minghao Zheng, Junjie Gao   +9 more
semanticscholar   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source