Results 101 to 110 of about 5,534,048 (331)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Therapy dogs as trustworthy facilitators in language-based emotional concept interventions for adolescents with adjustment difficulties

Human-Animal Interactions
In recent years, the increasing recognition of animal-assisted therapy (AAT) has prompted researchers to call for targeted studies focusing on specific age groups or disorders in the field of speech and language pathology.
Carmen Chia-Wen Ooi, Joanne Wing-Sum Wu, Natalie Tsz-Tung Lai, Noel Pui-Shan Tang   +3 more
doaj   +1 more source

Animal-assisted therapy used for anxiety disorders in patients with learning disabilities: An observational study [PDF]

, 2017
Introduction: Animal-assisted therapy is defined as the positive interaction between an animal and a patient within a therapeutic framework. Previous studies have reported on the beneficial effects of animal-assisted therapy with patients suffering from ...
Giuliani, Fabienne, Jacquemettaz, Morgane   +1 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

DOG THERAPY AS A METHOD OF SUPPORTING CHILDREN’S REHABILITATION PROCESS

Rozprawy Społeczne, 2019
Introduction The author of the article presents, on the basis of research, the benefits of using dog therapy in supporting the development and rehabilitation of children.
Sławomir Chrost
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

The impact of therapy dogs on perceptions of police officers

Human-Animal Interactions
Background: Amid national conversations about police accountability and injustice, therapy dogs in police stations may offer an innovative way to improve police-community interactions. This study examined the impact of therapy dog presence on perceptions
M.C. Delzio, M. Clements, K.E. Rodriguez
doaj   +1 more source

SPLENIC HOMOTRANSPLANTATION. [PDF]

, 1964
During the past 12 months, five clinical whole-organ splenic homotransplantations have been carried out with the objective of providing active immunologic tissue for the recipient patients.
FUDENBERG, H, MARCHIORO, TL, RIFKIND, D, ROWLANDS, DT, STARZL, TE, WADDELL, WR   +5 more
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

THE BENEFITS OF INCLUDING A THERAPY DOG FOR IMPROVING SOCIAL SKILLS OF A CHILD WITH MODERATE INTELLECTUAL DEVELOPMENT DISORDER

Innovative Issues and Approaches in Social Sciences
The article is about the role of a therapy dog for the development of social skills in a student with a moderate intellectual disability. Our chosen student attends a special education programme. In the research, we focused mostly on the student's social
Leja Ferlan, Erna Žgur
doaj   +1 more source