Results 101 to 110 of about 2,771,868 (291)

“Better Than Any Medicine:” Understanding How Therapy Dogs Support Patients Presenting with Mental Health and Substance Use Concerns in an Emergency Department Setting

Patient Experience Journal
In Canada, emergency departments have a large number of patients with mental health and substance use concerns passing through their doors. Our research aim was to assess the impact that therapy dog visits may have for patients presenting with mental ...
Alexandria R. Pavelich, Colleen A. Dell, James Stempien, Holly McKenzie, Aimee Hozack, Jane Smith, Alexis Rowsell, Janet Gunderson, Elizabeth Pease   +8 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Controlled clinical trial of canine therapy versus usual care to reduce patient anxiety in the emergency department.

PLoS ONE, 2019
ObjectiveTest if therapy dogs reduce anxiety in emergency department (ED) patients.MethodsIn this controlled clinical trial (NCT03471429), medically stable, adult patients were approached if the physician believed that the patient had "moderate or ...
Jeffrey A Kline, Michelle A Fisher, Katherine L Pettit, Courtney T Linville, Alan M Beck   +4 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Therapy Dog Welfare Revisited: A Review of the Literature. [PDF]

Vet Sci, 2021
Glenk LM, Foltin S.
europepmc   +1 more source

Man’s Best Friend or Man’s Best Therapist? Exploring the Barriers to Facilitating Dog-Assisted Therapy. [PDF]

Previous research has supported the efficacy of dog-assisted therapy, however, there continues to be a gap in the literature to explain why there are few opportunities to engage in this type of therapy.
Watts, Aislyn
core   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Remotely and collaboratively evaluating a campus-based therapy dog program during the COVID-19 pandemic. [PDF]

Eval Program Plann, 2023
Fletcher-Hildebrand S, Williamson L, Lawson K, Dell C.   +3 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

IS DOG THERAPY GOOD FOR THE THERAPY DOG?

, 2022
Therapy dogs have been used to support and even improve the health and emotional well-being of humans in a range of different settings. Over the past few decades, the use of animal-assisted interventions has increased dramatically, however, there is ...
Nicolson, Brianna Young
core   +1 more source