Results 131 to 140 of about 2,771,868 (291)

Monitoring of Rivaroxaban Therapy in Hypercoagulable Dogs

open access: yesJournal of Veterinary Internal Medicine
Abstract Background Measurement of rivaroxaban efficacy using the rivaroxaban-specific anti-Xa assay (raXa) can be used for monitoring in veterinary medicine. Detection of rivaroxaban efficacy using other hemostatic tests would make monitoring timelier and more accessible.
Erin M. Phillips   +5 more
openaire   +3 more sources

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

open access: yesFEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima   +8 more
wiley   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

open access: yesFEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla   +10 more
wiley   +1 more source

Dogoterapia w pracy logopedycznej

open access: yesLogopedia Silesiana, 2012
Pet therapy in the work of a logoped The article concerns talking the adventage of a therapy with the participation of a dog in the work of logoped. It presents the terminology connected with the pet therapy.
Marzena Machoś-Nikodem
doaj  

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

open access: yesFEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao   +10 more
wiley   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

open access: yesFEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa   +4 more
wiley   +1 more source

[Shannon Williams and Jodi Rhinehart-Doty petting therapy dog]

open access: yes, 2019
Photograph of Shannon Williams and Jodi Rhinehart-Doty petting a therapy dog in the Willis Library while the dog's handler holds the dog's leash and hands dog treats to Rachael ...
Esparza, Anna
core  

Effect of therapy dog on psychosocial development of pupils [PDF]

open access: yes, 2013
The diploma thesis describes the effect of animals on people, especially therapy dog on children or pupils and their psychosocial development. This paper discusses the impact of animal assisted therapy and animal assisted activity, their advantages and ...
Knez, Maja
core  

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

open access: yesFEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli   +2 more
wiley   +1 more source

A randomized controlled trial of the effects of dog-assisted versus robot dog-assisted therapy for children with autism or Down syndrome.

open access: yesPLoS ONE
Research with controlled or crossover designs in animal-assisted therapy have largely used control groups receiving no treatment or treatment as usual, which can potentially inflate the effects of these interventions.
Steffie Van Der Steen   +2 more
doaj   +1 more source

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