Results 1 to 10 of about 6,037 (68)

Modern view on the place of riociguat in the treatment of pulmonary hypertension [PDF]

Терапевтический архив, 2018
Current research is aimed at studying the fundamental therapeutic targets and discovering new drugs acting on previously set targets. Until recently, the only therapeutic strategy to influence the molecular pathway of nitric oxide (NO) - soluble ...
Z S Valieva, I N Taran, T V Martynyuk, I Ye Chazova   +3 more
doaj   +3 more sources

Optimization of specific therapy for pulmonary hypertension: the possibilities of riociguat

Терапевтический архив, 2021
Pulmonary hypertension (PH) is a severe and often rapidly progressive disease with fatal outcome. Endothelial dysfunction in PH is associated with decreased nitric oxide production.
Tamila V. Martynyuk, Anton A. Shmalts, Sergey V. Gorbachevsky, Irina E. Chazova   +3 more
doaj   +1 more source

Dual Nucleosomal Double-Strand Breaks Are the Key Effectors of Curative Radiation Therapy

Biophysica, 2023
Most ionizing radiation produces δ-rays of ≈1 keV that can impart MGy doses to 100 nm3 volumes of DNA. These events can produce severe dual double-strand breaks (DDSBs) on nucleosomes, particularly in dense heterochromatic DNA.
Anders Brahme, Yvonne Lorat
doaj   +1 more source

Contour Propagation for Radiotherapy Treatment Planning Using Nonrigid Registration and Parameter Optimization: Case Studies in Liver and Breast Cancer

Applied Sciences, 2022
Radiotherapy treatments are carried out using computerized axial tomography. In radiation therapy planning, the radiation oncologist must do a manual segmentation of volumes of interest to delineate the organs that should be irradiated.
Eliseo Vargas-Bedoya, Juan Carlos Rivera, Maria Eugenia Puerta, Aurelio Angulo, Niklas Wahl, Gonzalo Cabal   +5 more
doaj   +1 more source

Heart Failure Medical Therapy: A Review for Structural/Interventional Cardiologists

Structural Heart, 2022
Medical therapy for heart failure (HF) has expanded rapidly in the last decade contributing to improved morbidity and mortality for patients living with HF.
Alexandra Pipilas, MD, Trejeeve Martyn, MD, JoAnn Lindenfeld, MD   +2 more
doaj   +1 more source

Pharmacological Optimization of PSMA-Based Radioligand Therapy

Biomedicines, 2022
Prostate cancer (PCa) is the most common malignancy in men of middle and older age. The standard treatment strategy for PCa ranges from active surveillance in low-grade, localized PCa to radical prostatectomy, external beam radiation therapy, hormonal ...
Suzanne van der Gaag, Imke H. Bartelink, André N. Vis, George L. Burchell, Daniela E. Oprea-Lager, Harry Hendrikse   +5 more
doaj   +1 more source

Late airway obstruction and neutrophil infiltration in sensitized mice after antigen provocation were suppressed by selective and non-selective phosphodiesterase inhibitors

Allergology International, 1997
Suppression of antigen-induced late airway obstruction associated with neutrophilic inflammation by selective and non-selective phosphodiesterase (PDE) inhibitors was investigated in mice.
Osamu Kaminuma, Shinya Murakami, Matsunobu Suko, Hideo Kikkawa, Shigeki Matsubara, Wataru Toriumi, Katsuo Ikezawa, Hirokazu Okudaira, Koji Ito   +8 more
doaj   +1 more source

Interactive multiobjective optimization for finding the most preferred exercise therapy modality in knee osteoarthritis

Annals of Medicine, 2022
Background There are no explicit guidelines or tools available to support clinicians in selecting exercise therapy modalities according to the characteristics of individual patients despite the apparent need.
Babooshka Shavazipour, Bekir Afsar, Juhani Multanen, Kaisa Miettinen, Urho M. Kujala   +4 more
doaj   +1 more source

DenseNet_ HybWWoA: A DenseNet-Based Brain Metastasis Classification with a Hybrid Metaheuristic Feature Selection Strategy

Biomedicines, 2023
Brain metastases (BM) are the most severe consequence of malignancy in the brain, resulting in substantial illness and death. The most common primary tumors that progress to BM are lung, breast, and melanoma.
Abdulaziz Alshammari
doaj   +1 more source

Effectiveness of Epilepsy Therapy in Adults after Correction Performed by an Epileptologist

Неврология, нейропсихиатрия, психосоматика, 2014
Objective. To optimize the therapeutic and preventive care for epilepsy patients based on the results of examination and therapy correction performed by an epileptologist. Patients and Methods.
S. R. Nurmukhametova, R. V. Magzhanov
doaj   +1 more source