Results 61 to 70 of about 4,145,262 (262)

Risco cardiovascular em doentes com infecção por vírus da imunodeficiência humana.

Acta Médica Portuguesa, 2010
The increased cardiovascular risk has been implicated in both HIV infection and antirretroviral therapy. The endothelial dysfunction triggered by the infection and the metabolic abnormalities associated with therapy predispose to premature ...
Pedro Raimundo, A Miranda, J Ribeiro, Kamal Mansinho   +3 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Continuous subcutaneous foslevodopa/foscarbidopa infusion for the treatment of motor fluctuations in Parkinson’s disease: Considerations for initiation and maintenance

Clinical Parkinsonism & Related Disorders
Background: As Parkinson's disease (PD) advances, management is challenged by an increasingly variable and inconsistent response to oral dopaminergic therapy, requiring special considerations by the provider.
Victor S.C. Fung, Jason Aldred, Martha P. Arroyo, Filip Bergquist, Agnita J.W. Boon, Manon Bouchard, Sarah Bray, Sara Dhanani, Maurizio F. Facheris, Nahome Fisseha, Eric Freire-Alvarez, Robert A. Hauser, Anna Jeong, Jia Jia, Pavnit Kukreja, Michael J. Soileau, Amy M. Spiegel, Saritha Talapala, Arjun Tarakad, Enrique Urrea-Mendoza, Jorge Zamudio, Rajesh Pahwa   +21 more
doaj   +1 more source

Optimizing antimicrobial therapy in children [PDF]

Journal of Infection, 2016
Management of common infections and optimal use of antimicrobial agents are presented, highlighting new evidence from the medical literature that enlightens practice. Primary therapy of staphylococcal skin abscesses is drainage. Patients who have a large abscess (>5 cm), cellulitis or mixed abscess-cellulitis likely would benefit from additional ...
openaire   +2 more sources

Narrative therapy, family therapy and history [PDF]

, 2009
This article was inspired by listening to the interesting plenary on the influence of narrative therapy on family therapy at the AFT annual conference in Manchester in September 2008.
Harper, David
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Targeted lung cancer therapy: preparation and optimization of transferrin-decorated nanostructured lipid carriers as novel nanomedicine for co-delivery of anticancer drugs and DNA

International Journal of Nanomedicine, 2015
Zhenyu Shao,1 Jingyu Shao,2 Bingxu Tan,1 Shanghui Guan,1 Zhulong Liu,1 Zengjun Zhao,1 Fangfang He,1 Jian Zhao3 1Department of Radiotherapy, Cancer Centre, Qilu Hospital, Shandong University, Ji’nan, Shandong, People’s Republic of China ...
Shao Z, Shao J, Tan B, Guan S, Liu Z, Zhao Z, He F, Zhao J   +7 more
doaj  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Multiobjective, Multidelivery Optimization for Radiation Therapy Treatment Planning

Advances in Radiation Oncology, 2020
Purpose: To introduce multiobjective, multidelivery optimization (MODO), which generates alternative patient-specific plans emphasizing dosimetric trade-offs and conformance to quasi-constrained (QC) conditions for multiple delivery techniques.
William Tyler Watkins, PhD, Hamidreza Nourzadeh, PhD, Jeffrey V. Siebers, PhD   +2 more
doaj   +1 more source

Occupational Therapy's Role in Hand Therapy: Approaches and Perspectives

, 2021
Indiana University Purdue University IndianapolisHand therapy is a practice area within occupational therapy. Occupational therapists have a unique skillset in which they are able to treat patients with upper extremity musculoskeletal injuries while ...
Shelton, Hayley
core   +1 more source