Results 101 to 110 of about 2,406,580 (299)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Geothermal exploration permit application for Puna Geothermal Venture to conduct a controlled source audio magnetotelluric survey

, 1986
Submitted to the Department of Land and Natural Resources, State of Hawaii."Thermal Power Company (Thermal), Operator for the Puna Geothermal Venture (PGV), herein submits an application for a Geothermal Exploration Permit to conduct a Controlled Source ...
Thermal Power Company
core  

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Thermal Analysis for Condition Monitoring of Machine Tool Spindles

, 2012
Decreasing tolerances on parts manufactured, or inspected, on machine tools increases the requirement to have a greater understanding of machine tool capabilities, error sources and factors affecting asset availability. Continuous usage of a machine tool
Willoughby, P., Longstaff, Andrew P., Longstaff, A. P., Fletcher, Simon, Willoughby, Peter, Clough, D., Fletcher, S., Clough, David A   +7 more
core   +1 more source

ANALYSIS OF THERMAL TRANSFER VALUES IN TEACHING CLASSROOMS

Al-Ulum
Erratic weather, such as intense heat followed by heavy rain, is causing air pollution in the sky of Jakarta. According to the SNI 03-6389-2011, which deals with energy conservation in building envelopes, the overall thermal transfer value (OTTV) for ...
Tri Wulan Sari, Dyah Nurwidyaningrum, Jonathan Saputra, Denny Yatmadi, Sujito Sujito   +4 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Thermal Conductivity of Carbon Nanotubes and their Polymer Nanocomposites: A Review [PDF]

, 2011
Thermally conductive polymer composites offer new possibilities for replacing metal parts in several applications, including power electronics, electric motors and generators, heat exchangers, etc., thanks to the polymer advantages such as light weight ...
Fina, Alberto, Han, Zhidong, Zhidong Han, Alberto Fina   +3 more
core   +1 more source

Visualizing the Spatiotemporal Trends of Thermal Characteristics in a Peatland Plantation Forest in Indonesia: Pilot Test Using Unmanned Aerial Systems (UASs)

Remote Sensing, 2018
The high demand for unmanned aerial systems (UASs) reflects the notable impact that these systems have had on the remote sensing field in recent years.
Kotaro Iizuka, Kazuo Watanabe, Tsuyoshi Kato, Niken Andika Putri, Sisva Silsigia, Taishin Kameoka, Osamu Kozan   +6 more
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source