Results 81 to 90 of about 2,406,580 (299)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Porous materials for thermal management under extreme conditions [PDF]

, 2006
A brief analysis is presented of how heat transfer takes place in porous materials of various types. The emphasis is on materials able to withstand extremes of temperature, gas pressure, irradiation, etc., i.e.
T.W Clyne, Clyne, T.W., Markaki, AE, Golosnoy, I.O., Tan, J.C., Clyne, TW, J.C Tan, ,, Markaki, A.E., A.E Markaki, Tan, Jin Chong, Golosnoy, IO, I.O Golosnoy, Tan, JC   +13 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Thermal conductivity measurement of liquids in a microfluidic device

, 2010
A new microfluidic-based approach to measuring liquid thermal conductivity is developed to address the requirement in many practical applications for measurements using small (microlitre) sample size and integration into a compact device.
M. R. Bown, Newton, M.I., Allen, RWK, Allen, R. W.K., Ge, Rile, Ge, R., Kuvshinov, Dmitriy, Newton, MI, Bown, MR, MacInnes, J. M., Hardacre, C., Hardacre, C.; id_orcid, Doy, N., McHale, G., Allen, R. W K, Newton, Michael, Bown, Mark, Aldous, L., Allen, R.W.K., Newton, M. I., Hardacre, C, R. Ge, McHale, G, Hardacre, Christopher, N. Doy, D. Kuvshinov, Allen, Ray, Doy, Nicola, Kuvshinov, D., Bown, M.R., L. Aldous, MacInnes, Jordan, R. W. K. Allen, Allen, R. W. K., MacInnes, JM, McHale, Glen, J. M. MacInnes, Doy, N, G. McHale, Aldous, Leigh, C. Hardacre, Ge, R, MacInnes, J.M., M. I. Newton, Aldous, L, Kuvshinov, D, Bown, M. R.   +46 more
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Evolution and Modern Approaches for Thermal Analysis of Electrical Machines [PDF]

, 2009
In this paper, the authors present an extended survey on the evolution and the modern approaches in the thermal analysis of electrical machines. The improvements and the new techniques proposed in the last decade are analyzed in depth and compared in ...
Shanel, M., D. STATON, M. SHANEL, Aldo Boglietti, Andrea Cavagnino, C. MEJUTO, Carlos Mejuto, David Staton, M. MUELLER, Mueller, M., Staton, D., Mejuto, C., Martin Shanel, Boglietti, Aldo, Cavagnino, Andrea, Markus Mueller   +15 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Thermal stresses in pipes [PDF]

, 2002
This study presents results about thermal stresses in externally heated pipes that are subjected to different flow types: laminar flow, turbulent flow, and pulsating flow. The effect o f flow Reynolds number on thermal stresses in the pipe is studied. To
Al-Zaharnah, Iyad
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Thermal pions [PDF]

Nuclear Physics A, 1994
7 pp, LaTeX, uses espcrc1.sty from North-Holland Publishing, BUTP-93 ...
openaire   +2 more sources