Results 81 to 90 of about 2,057,640 (253)
Science and Engineering of Composite Materials, 2017 Stress-strain analysis has been an interesting issue for the mechanical design of composite structures. In this paper, a three-dimensional mechanical model based on generalized method of cells is presented to study the thermal residual stress and loading
Ye Junjie +5 more
doaj +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Unobtrusive Respiratory Flow Monitoring Using a Thermopile Array: A Feasibility Study
Applied Sciences, 2019 Low-resolution thermal cameras have already been used in the detection of respiratory flow. However, microbolometer technology has a high production cost compared to thermopile arrays.
Ilde Lorato +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Parametric study on the thermal performance enhancement of a thermosyphon heat pipe using covalent functionalized graphene nanofluids [PDF]
, 2020 Heat transfer characteristics of copper sintered heat pipe explored using a modified graphene nanoplatelets (GNP)-containing nanofluid with great dispersion stability as a novel working fluid.
Sadeghinezhad, Emad +5 more
core +2 more sources
Evaluation of Polymer Matrix Composite Waste Recycling Methods
Environmental and Climate Technologies, 2019 Polymer-based matrix composite materials are in high demand in many different fields: aeronautics, pressure vessel manufacturing, wind turbine blade manufacturing, and others.
Delvere Ieva +5 more
doaj +1 more source