Results 41 to 50 of about 1,041,899 (269)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Thermal-Aware Design Space Exploration of 3-D Systolic ML Accelerators

IEEE Journal on Exploratory Solid-State Computational Devices and Circuits, 2021
Machine learning (ML) accelerators have a broad spectrum of use cases that pose different requirements on accelerator design for latency, energy, and area. In the case of systolic array-based ML accelerators, this puts different constraints on processing
Rahul Mathur, Ajay Krishna Ananda Kumar, Lizy John, Jaydeep P. Kulkarni   +3 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Surface and intradermal temperature responses of adults to ambient heat stress with and without cooling

Physiological Reports
Accurate measurement of skin temperature is crucial to understanding responses to heat. We tested the hypothesis that intradermal temperature would differ from skin surface temperature during ambient heating with and without fan and water spray (24°C ...
Zachary J. McKenna, Elizabeth A. Gideon, Erin M. Harper, Taysom E. Wallace, Isa A. Farooqi, Craig G. Crandall   +5 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Synthesis, Characterization and Thermal Study of Polyimides Derived from Polystyrene [PDF]

مجلة جامعة الانبار للعلوم الصرفة, 2012
A novel polyimides of polystyrene with high thermal stability were prepared by the reaction of aminated polystyrene with Benzophenone tetracarboxylic dianhydride.
Abdulsalam A. Shyaa
doaj   +1 more source

Remote Sensing Energy Balance Model for the Assessment of Crop Evapotranspiration and Water Status in an Almond Rootstock Collection

Frontiers in Plant Science, 2021
One of the objectives of many studies conducted by breeding programs is to characterize and select rootstocks well-adapted to drought conditions. In recent years, field high-throughput phenotyping methods have been developed to characterize plant traits ...
Joaquim Bellvert, Héctor Nieto, Ana Pelechá, Christian Jofre-Čekalović, Lourdes Zazurca, Xavier Miarnau   +5 more
doaj   +1 more source

Fundamentals of Thermal Expansion and Thermal Contraction

Materials, 2017
Thermal expansion is an important property of substances. Its theoretical prediction has been challenging, particularly in cases the volume decreases with temperature, i.e., thermal contraction or negative thermal expansion at high temperatures. In this paper, a new theory recently developed by the authors has been reviewed and further examined in the ...
Zi-Kui Liu, Shun-Li Shang, Yi Wang
openaire   +2 more sources