Results 31 to 40 of about 160,361 (258)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Landsat-8 and Sentinel-2 multispectral surface reflectance data differentiated moisture levels in oak and pine forests in Mediterranean arid environments

Forest Science and Technology
Forests play a critical role in climate regulation by acting as carbon sinks, reducing atmospheric carbon dioxide and mitigating climate change. Early detection of low plant moisture levels is essential for monitoring drought conditions in forests.
Yahia A. Othman, Kholoud M. Alananbeh, Monther M. Tahat, Ansam A. Ghlelat, Sameh Alkhatatbeh, Rowaa O. Alawi, Hothifah Al-Zyout, Mohammad Al-Zyoud   +7 more
doaj   +1 more source

Simulation-assisted investigation on the formation of layer bands and the microstructural evolution in directed energy deposition of Ti6Al4V blocks

Virtual and Physical Prototyping, 2021
Additive manufacturing (AM) of titanium alloy entails severe microstructural heterogeneity and layer bands due to diverse thermal histories. While the thermal-microstructure relationship in AM has been reported, the details on how complex thermal ...
Xufei Lu, Guohao Zhang, Junjie Li, Miguel Cervera, Michele Chiumenti, Jing Chen, Xin Lin, Weidong Huang   +7 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

TESTING BRIGHTNESS ADJUSTED DUST INDEX (BADI) TO DETECT DUST STORMS IN CLOUDY WEATHER OVER IRAQ, CASE STUDY

The Iraqi Journal of Agricultural science
Dust storms are frequent in many arid and semi-arid regions of the world; they are a significant environmental hazard that impacts human health, agriculture, transportation, and ecosystems, and their frequency and intensity are being magnified by ...
Mohammed Jassim, Thaer Roomi, Yaseen Abbas   +2 more
doaj   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Emittance Spectroscopy and Broadband Thermal Remote Sensing Applied to Phosphorite and Its Utility in Geoexploration: A Study in the Parts of Rajasthan, India

Remote Sensing, 2019
The contrast in the emissivity spectra of phosphorite and associated carbonate rock can be used as a guide to delineate phosphorite within dolomite. The thermal emissivity spectrum of phosphorite is characterized by a strong doublet emissivity feature ...
Arindam Guha, Yasushi Yamaguchi, Snehamoy Chatterjee, Komal Rani, Kumranchat Vinod Kumar   +4 more
doaj   +1 more source