Results 61 to 70 of about 1,410,120 (306)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The Impact of Modified Metallic Nanoparticles on Thermomechanical Properties of PMMA Soft Liner

Nano Biomedicine and Engineering, 2023
The acrylic-based heat-cured soft denture lining material is the most commonly used in relining dentures. This material has poor thermomechanical properties which is a disadvantage.
Ban Saad Jasim, Hasanain K.A. Alalwan, Abdalbseet A. Fatalla, Manar E. Al-Samaray   +3 more
doaj   +1 more source

Quantum relaxation after a quench in systems with boundaries

, 2011
We study the time-dependence of the magnetization profile, m_l(t), of a large finite open quantum Ising chain after a quench. We observe a cyclic variation, in which starting with an exponentially decreasing period the local magnetization arrives to a ...
Iglói, Ferenc, Rieger, Heiko
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Reply to "Comment on 'Light-Front Schwinger Model at Finite Temperature'"

, 2003
In hep-th/0310278, Blankleider and Kvinikhidze propose an alternate thermal propagator for the fermions in the light-front Schwinger model. We show that such a propagator does not describe correctly the thermal behavior of fermions in this theory and, as
A. Das, A. Das, Ashok Dos, B. Blankleider, G. McCartor, G. McCartor, H.A. Weldon, P.P. Srivastava, P.P. Srivastava, V.S. Alves, Xingxiang Zhou   +10 more
core   +1 more source

Crack-Resistance Behavior of an Encapsulated, Healing Agent Embedded Buffer Layer on Self-Healing Thermal Barrier Coatings [PDF]

, 2019
In this work, a novel thermal barrier coating (TBC) system is proposed that embeds silicon particles in coating as a crack-healing agent. The healing agent is encapsulated to avoid unintended reactions and premature oxidation.
Choi, Baig-Gyu, Jung, Yeon-Gil, Kim, In-Soo, Lyu, Guanlin, Paik, Ungyu, Song, Dowon, Song, Taeseup, Zhang, Jing   +7 more
core   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Heat Effects during the Operation of Lead-Acid Batteries

Batteries
Thermal events in lead-acid batteries during their operation play an important role; they affect not only the reaction rate of ongoing electrochemical reactions, but also the rate of discharge and self-discharge, length of service life and, in critical ...
Petr Bača, Petr Vanýsek, Martin Langer, Jana Zimáková, Ladislav Chladil   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Psychrophilic Full Scale Tubular Digester Operating over Eight Years: Complete Performance Evaluation and Microbiological Population

Energies, 2020
Most biogas plants in the world run under psychrophilic conditions and are operated by small and medium farmers. There is a gap of knowledge on the performance of these systems after several years of operation.
Jaime Jaimes-Estévez, German Zafra, Jaime Martí-Herrero, Guillermo Pelaz, Antonio Morán, Alejandra Puentes, Christian Gomez, Liliana del Pilar Castro, Humberto Escalante Hernández   +8 more
doaj   +1 more source