Results 91 to 100 of about 203,544 (317)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Power system real-time thermal rating estimation [PDF]
, 2010 This Thesis describes the development and testing of a real-time rating estimation algorithm developed at Durham University within the framework of the partially Government-funded research and development project “Active network management based on ...
MICHIORRI, ANDREA
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Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Transient Heat Transfer at the Building-Soil Boundary [PDF]
Constructii: Journal of Civil Engineering Research, 2010 The thermal flow transferred through the soil represents an important rate of the thermal flow dissipated to the outside by the buildings, mainly by the low ones.
Dan CONSTANTINESCU
doaj
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Machine structure simulation using FEA and optimised thermal parameters
, 2015 Continuous usage of machine tools during manufacturing processes causes heat generation in the moving elements, resulting in distortion of the machine tool structure.
Longstaff, Andrew P. +3 more
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FEBS Open Bio, EarlyView.Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu +10 more
wiley +1 more source
Chengshi guidao jiaotong yanjiuObjective According to the characteristics of urban rail transit aluminum-alloy vehicle enclosure structure，a K-value calculation method based on thermal resistance model is studied, thereby improving calculation accuracy and efficiency. Method The above
WANG Yunxiao, WANG Jing, TAN Wencai
doaj +1 more source
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Novel and efficient thermal error reduction strategy for machine tool performance improvement
, 2008 The accuracy of a machine tool is affected by the heat generated during the machining process. Also, varying environmental conditions produce thermal gradients that flow through the machine structure.
Longstaff, Andrew P. +4 more
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