Results 51 to 60 of about 7,438,682 (259)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Parametric study on the thermal performance enhancement of a thermosyphon heat pipe using covalent functionalized graphene nanofluids [PDF]

, 2020
Heat transfer characteristics of copper sintered heat pipe explored using a modified graphene nanoplatelets (GNP)-containing nanofluid with great dispersion stability as a novel working fluid.
Sadeghinezhad, Emad, Mehrali, Mohammad, Tahan Latibari, Sara, Mehrali, Mehdi, Akhiani, Amir Reza, Metselaar, Hendrik Simon Cornelis   +5 more
core   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Novel Self-Dyed Wholly Aromatic Polyamide-Hydrazides Covalently Bonded with Azo Groups in Their Main Chains: 1. Structure-Property Relationships

Molecules, 2012
Twelve novel intrinsically colored wholly aromatic azopolyamide-hydrazides containing various proportions of para- and meta-phenylene units were successfully synthesized by a low temperature (−10 °C) solution polycondensation reaction ...
Nadia A. Mohamed, Mohammad H. Sammour, Ali M. Elshafai   +2 more
doaj   +1 more source

Melting of PCM in a thermal energy storage unit: Numerical investigation and effect of nanoparticle enhancement [PDF]

, 2012
The present paper describes the analysis of the melting process in a single vertical shell-and-tube latent heat thermal energy storage (LHTES), unit and it is directed at understanding the thermal performance of the system.
Sciacovelli, Adriano, Verda, Vittorio, Colella, F., Colella F.   +3 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Effect of ultrasonic, thermal and ozone pre-treatments on waste activated sludge solubilisation and anaerobic biodegradability [PDF]

, 2006
In order to enhance the efficiency of anaerobic digestion, the effects of ultrasounds, ozonation and thermal pre-treatment have been studied on waste activated sludge.
Xin Tian, Darmency, Henri, Bougrier, Claire, Delgenès, Jean-Philippe, Carrère, Hélène, Albasi, Claire, Tian, Xin, Henri Darmency   +7 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Numerical investigation of heat and mass transfer processes in the combustion chamber of industrial power plant boiler. Part 1. Flow field, temperature distribution, chemical energy distribution

Applied and Computational Mechanics, 2017
In the present paper, the furnace chamber of the BKZ-160 boiler of Almaty TPP-3 (Kazakhstan) has been calculated. The thermal characteristics of the process were studied in the form of the distribution of temperature fields and chemical energy, and the ...
Askarova A., Maximov V., Bolegenova S., Bolegenova S., Yergaliyev A., Šafařík P.   +5 more
doaj   +1 more source

Coriolis effects and the thermal bar [PDF]

, 2002
A model for the thermal bar system in the rotating frame that includes unsteady inertia is formulated. Asymptotic solutions are found to the initial value problem in the frictionless, small bottom slope limit.
Farrow, D.E.
core