Results 191 to 200 of about 2,719,034 (384)

Lipid metabolism reprograming by SREBP1‐PCSK9 targeting sensitizes pancreatic cancer to immunochemotherapy

open access: yesCancer Communications, EarlyView.
Abstract Background Pancreatic cancer's aberrant lipid metabolism fuels cell growth, invasion, and metastasis, yet its impact on immune surveillance and immunotherapy is unclear. This study investigated how sterol regulatory element‐binding transcription factor 1 (SREBP1)‐driven lipid metabolism affects the tumor microenvironment (TME) in pancreatic ...
Mengyi Lao   +12 more
wiley   +1 more source

A De Novo Designed Metalloprotein Displays Variable Thermal Stability and Binding Stoichiometry with Transition Metal Ions

open access: yesChemBioChem, EarlyView.
A de novo designed single‐chain coiled coil protein is unfolded in apo‐state but folds up upon addition of divalent transition metal ions Co(II), Ni(II), Cu(II), and Zn(II). The resulting metal‐bound complexes exhibit distinct thermal stability and metal stoichiometry, making this protein a promising starting point for the design of fully metal ...
Britt Rooijakkers   +4 more
wiley   +1 more source

Dynamic Transition Associated with the Thermal Denaturation of a Small Beta Protein [PDF]

open access: bronze, 2002
Daniela Russo   +4 more
openalex   +1 more source

Advancing Biocatalysis: Using Siloxanes to Solubilize and Stabilize Enzymes in Organic Solvents

open access: yesChemCatChem, EarlyView.
Biocatalysis offers an attractive route in the development of more sustainable approaches in silicon chemistry. Given the propensity for enzymes to operate optimally in an aqueous environment there are obvious challenges to incorporating biocatalysts in organic solvents.
Najibeh Alizadeh   +2 more
wiley   +1 more source

Thermal Denaturation of Fresh Frozen Tissue Enhances Mass Spectrometry Detection of Peptides. [PDF]

open access: yesAnal Chem
Kruse ARS   +9 more
europepmc   +1 more source

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