Results 31 to 40 of about 2,387,534 (245)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Thermo-Elastic Structural Analysis of a Machine Tool Using a Multi-Channel Absolute Laser Interferometer

Journal of Machine Engineering, 2020
One of the main errors in the machining accuracy of machine tools is the displacement through thermal induced deformation. Modern design and construction methods aim to optimize the heat flow in the machine to achieve minimum displacement.
Jessica DEUTSCH, Tom ALBRECHT, Mirko RIEDEL, Lars PENTER, Hajo WIEMER, Jens MÜLLER, Steffen IHLENFELDT   +6 more
doaj   +1 more source

Incorporating cooling and ventilation effects into a single IEQ indicator [PDF]

E3S Web of Conferences, 2019
The influence of dissimilar cooling and ventilation system combinations on indoor environmental quality (IEQ) has been studied. A comparison of chilled ceiling cooling in combination with displacement ventilation, cooling with fan coil unit, and cooling ...
Prek Matjaž, Krese Gorazd, Lampret Žiga   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Stacking ensemble transfer learning based thermal displacement prediction system

International Journal of Optomechatronics, 2023
In the precision machining industry, machine tools are usually affected by various factors during machining, and various machining errors generated accordingly.
Ping-Huan Kuo, Chia-Ho Lee, Her-Terng Yau   +2 more
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Thermally induced displacements and post-thermal shear behavior of soil-structure interfaces using a modified triaxial apparatus

Case Studies in Thermal Engineering
The mechanical behavior of energy pile–soil interfaces is significantly influenced by temperature variations, especially under cyclic thermal loading. This study presents an experimental investigation using a modified triaxial apparatus to evaluate the ...
Chunhong Li, Sunan Cao, Zhiwei Liu, Yaohu Hao   +3 more
doaj   +1 more source

Thermal quadrupole method with internal heat sources [PDF]

, 2012
A new method based on the thermal quadrupoles technique for heat transfer modelling in multilayered slabs with heat sources is proposed. Classical thermal quadrupoles use hyperbolic functions and numerical problems occur according to the argument value ...
A. Kusiak, BATTAGLIA, Jean-Luc, PRADERE, Christophe, KUSIAK, Andrzej, PAILHES, Jerome, Batsale, J.-C., AREGBA, Aworou Waste, A.W. Aregba, TOUTAIN, Jerome, Aregba, A.W., AREGBA, Waste, J.-C. Batsale, C. Pradere, Kusiak, A., TOUTAIN, Jean, J. Toutain, J. Pailhes, Toutain, J., Pailhes, J., BATSALE, Jean-Christophe, Battaglia, J.-L., J.-L. Battaglia   +21 more
core   +1 more source