Results 41 to 50 of about 6,138,248 (244)

A Numerical Analysis on Flow and Heat Transfer in the Entrance Region of an Axially Rotating Pipe

open access: yesInternational Journal of Rotating Machinery, 1995
A numerical study is performed to investigate turbulent flow and heat transfer characteristics in the entrance region of a pipe rotating around its axis.
Shuichi Torii, Wen-Jei Yang
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

Thermally Developing Flow and Heat Transfer in Elliptical Minichannels with Constant Wall Temperature

open access: yesMicromachines, 2019
Laminar convective heat transfer of elliptical minichannels is investigated for hydrodynamically fully developed but thermal developing flow with no-slip condition.
Liangbin Su   +4 more
doaj   +1 more source

Nanofluid flow and heat transfer of carbon nanotube and graphene platelette nanofluids in entrance region of microchannels

open access: yesArchives of Mechanics, 2020
Suspensions of nano-scale particles in liquids, dubbed nanofluids, are of great interest for heat transfer applications. Nanofluids potentially offer superior thermal conductivity to alternative, pure fluids and are of particular interest in applications
M.E. Fuller, J.T.C. Liu
doaj   +1 more source

Exact solution for the conjugate fluid-fluid problem in the thermal entrance region of laminar counterflow heat exchangers [PDF]

open access: yes, 2011
A generalized Lévêque solution is presented for the conjugate fluid–fluid problem that arises in the thermal entrance region of laminar counterflow heat exchangers.
Liñán Martínez, Amable   +1 more
core   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

open access: yesFEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda   +4 more
wiley   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

open access: yesFEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Developing Heat Transfer for Laminar Flow of Power-law Fluids in the Entrance Region of a Pipe

open access: yes, 2022
A Master of Science thesis in Chemical Engineering by Muhammad Faheem Hassan entitled, “Developing Heat Transfer for Laminar Flow of Power-law Fluids in the Entrance Region of a Pipe”, submitted in June 2022. Thesis advisor is Dr. Rachid Chebbi.
Hassan, Muhammad Faheem
core  

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