Results 51 to 60 of about 443,795 (288)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Modeling of Thermal Traces Using Fractional Order, a Discrete, Memory-Efficient Model
Energies, 2022 In the paper, the problem of modeling of thermal traces is addressed. The proposed model allows prediction of the behaviour of a thermal mark left by a warm body on cooler ground. In the model, a fractional order (FO) approach is employed.
Krzysztof Oprzędkiewicz +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
GMOSS: All-sky model of spectral radio brightness based on physical components and associated radiative processes [PDF]
, 2016 We present Global MOdel for the radio Sky Spectrum (GMOSS) -- a novel, physically motivated model of the low-frequency radio sky from 22 MHz to 23 GHz.
Chluba, Jens +3 more
core +3 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Analytical modeling for thermal errors of motorized spindle unit [PDF]
International Journal of Machine Tools and Manufacture, 2017 Modeling method investigation about spindle thermal errors is significant for spindle thermal optimization in design phase. To accurately analyze the thermal errors of motorized spindle unit, this paper assumes approximately that 1) spindle linear thermal error on axial direction is ascribed to shaft thermal elongation for its heat transfer from ...
Liu, Teng +6 more
openaire +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Macro Modeling of V-Shaped Electro-Thermal MEMS Actuator with Human Error Factor
Micromachines, 2021 The V-shaped electro-thermal MEMS actuator model, with the human error factor taken into account, is presented in this paper through the cascading ANSYS simulation model and the Fuzzy mathematics calculation model. The Fuzzy mathematics calculation model
Dongpeng Zhang +3 more
doaj +1 more source
Model Reduction for Multiscale Lithium-Ion Battery Simulation
, 2016 In this contribution we are concerned with efficient model reduction for multiscale problems arising in lithium-ion battery modeling with spatially resolved porous electrodes.
A. Latz +15 more
core +1 more source
FEBS Open Bio, EarlyView.We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima +4 more
wiley +1 more source