Results 81 to 90 of about 20,614 (298)

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

A study on infrared thermometer measurement capabilities in the calibration laboratories and the user community in Japan

SICE Journal of Control, Measurement, and System Integration, 2021
A comparison circulating a standard infrared thermometer, a handy infrared thermometer, and a thermal imager was conducted among eleven participants from the industrial user, academic user, and calibration laboratory communities of these thermometers in ...
Yoshiro Yamada, Tomonori Kato, Takao Shimizu, Juntaro Ishii, Kouichi Iguchi, Kenji Ishikawa, Hiroyuki Honjo, Naohiro Ohsuga, Yoshinori Onda, Kaori Suzuki, Katsunori Tsuda, Takayuki Yamakawa, Takahiro Yamazaki   +12 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Multispectral Thermal Imager - Overview [PDF]

, 2001
The Multispectral Thermal Imager satellite fills a new and important role in advancing the state of the art in remote sensing sciences. Initial results with the full calibration system operating indicate that the system was already close to achieving the
Bell, W. Randy, Weber, Paul G.
core  

Retrieval of sea surface temperature from space based on modeling of infrared radiative transfer: capabilities and limitations [PDF]

, 2004
The retrieval (estimation) of sea surface temperatures (SSTs) from space-based infrared observations is increasingly performed using retrieval coefficients derived from radiative transfer simulations of top-of-atmosphere brightness temperatures (BTs ...
Merchant, Christopher J., Le Borgne, Pierre, Merchant, C. J., Le Borgne, P.   +3 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Reflective all-sky thermal infrared cloud imager [PDF]

, 2018
A reflective all-sky imaging system has been built using a long-wave infrared microbolometer camera and a reflective metal sphere. This compact system was developed for measuring spatial and temporal patterns of clouds and their optical depth in support ...
Shaw, Joseph A., Clark, R. Trevor, Paul W. Nugent, Sabino Piazzolla, Nugent, Paul W., R. Trevor Clark, Redman, Brian J., Piazzolla, Sabino, Joseph A. Shaw, Brian J. Redman   +9 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Quantifying Thermal‐Imager Effectiveness for Detecting Bird Nests on Farms [PDF]

, 2019
We conducted a designed experiment to test whether having a thermal‐imaging camera available affected researchers’ nest detection rates when searching for bird nests in cropland and grassland habitat in an agricultural landscape of Iowa, USA, in 2016 ...
Klaver, Robert, Stephenson, Matthew, Schulte, Lisa, Schulte Moore, Lisa   +3 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source