Results 191 to 200 of about 77,462 (276)

Ixekizumab With Tirzepatide Achieved Greater Disease Control Than Ixekizumab Alone in Adults With Psoriatic Arthritis and Overweight or Obesity: Results From a Randomized Clinical Trial

Arthritis &Rheumatology, EarlyView.
Objective Overweight or obesity is prevalent in 72% to 82% of individuals with psoriatic arthritis (PsA). We assessed the efficacy and safety of ixekizumab (IXE) concomitantly administered with tirzepatide (TZP) compared with IXE alone in adult participants with active PsA and overweight with at least one weight‐related comorbidity or obesity.
Joseph F. Merola, Philip Mease, Alan Kivitz, Naveed Sattar, Laura C. Coates, Daniel Aletaha, Cynthia E. Kartman, Peter Fischer, Luna Sun, Píndaro Martínez‐Osuna, Andris Kronbergs, Purvi Prajapati, Anabela Cardoso, Mark C. Genovese, Alexis Ogdie   +14 more
wiley   +1 more source

Fibrosis-Driven Surgical Risk After Thyroid Nodule Ablation: Quantitative Clinicopathological Determinants of Complications in Post-Ablative Thyroidectomy-A Retrospective Cohort Study. [PDF]

World J Surg
Zhang D, Boero A, Gazzano G, Satta A, Fugazzola L, Colombo C, Brucchi F, Dionigi G.   +7 more
europepmc   +1 more source

Fresh Talus Allograft Preparation for the Treatment of a Large Off‐Track Hill‐Sachs Lesion

Arthroscopy Techniques, EarlyView.
Abstract Large off‐track Hill‐Sachs lesions present a significant challenge in the management of recurrent anterior shoulder instability, particularly in young, active patients. Traditional Hill‐Sachs management procedures include remplissage, coracoid transfer and free bone block reconstruction, which all carry associated limitations, including non ...
Michael J. Nocek, Mikalyn T. DeFoor, Taylor Calibo, Nate J. Dickinson, Madeleine Blankenship, Matthew T. Provencher   +5 more
wiley   +1 more source

Efficacy and Safety of Microwave Ablation for Osteoid Osteoma: A Retrospective Analysis of 35 Cases. [PDF]

J Orthop Case Rep
Davis D, John J, John A, Puthur KD.
europepmc   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Radiofrequency, Cryoablation, and Pulsed Field Ablation for Atrial Fibrillation: Mechanisms, Preclinical Evidence, and Clinical Outcomes. [PDF]

Biomedicines
Mihordea A, Puiu M, Simu G, Minciuna IA, Rosu R, Gusetu G, Pop D, Cismaru G.   +7 more
europepmc   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Non-Temperature-Induced Antitumor Effects of Amplitude-Modulated Radiofrequency: Molecular and Functional Synergies with Radiotherapy. [PDF]

Cancers (Basel)
Veltsista PD, Walther W, Torke S, Ivanov A, Dieper A, Beule D, Zips D, Stein U, Ghadjar P.   +8 more
europepmc   +1 more source

New opportunities for bioscaffold‐enabled spinal cord injury repair

BMEMat, EarlyView.
Schematic illustration of bioscaffolds for spinal cord injury repair. We summarize the effects of bioscaffold properties on SCI repair, highlight different types of bioscaffolds, various fabrication strategies, and in vivo transformations for the clinical development of SCI‐repairing bioscaffolds.
Xiaoqing Qi, Yicheng Fu, Zhaoliang Su, Li Li, Subrata Chakrabarti, Peng Li, Yilun Wu, Fang Liu, Teng Gao, Zhifeng Dong, Lei Liu, Pei Cao   +11 more
wiley   +1 more source

Magnetic resonance-guided focused ultrasound surgery for adenomyosis: current evidence and future directions. [PDF]

Front Med (Lausanne)
Li Y, Yang Z, Xu X.
europepmc   +1 more source