Results 111 to 120 of about 6,447 (219)
The R203W substitution drives PACS‐1 syndrome by disrupting intramolecular regulation
The FEBS Journal, EarlyView.The middle region (MR) of PACS‐1 controls engagement with specific partner proteins. This manuscript presents the structure of the Furin binding region (FBR) and how interactions with partners are regulated through the interplay between a basic patch in the FBR and an acidic cluster in the MR.
Troy C. Krzysiak +7 more
wiley +1 more source
Advanced ScienceHuman dental pulp stem cells (hDPSCs) are dental‐derived mesenchymal stem cells with robust multipotent differentiation potentials, rendering them promising for bone tissue engineering.
Yu Wu +9 more
doaj +1 more source
Combating ageing beyond the cell: Emerging roles of extracellular proteostasis
The FEBS Journal, EarlyView.Ageing challenges the body's ability to maintain a stable and functional proteome, leading to protein damage and aggregation both inside and outside cells. This review focuses on the less well understood mechanisms of extracellular protein quality control and how they become disrupted in ageing, particularly in neurodegenerative diseases.
Siddharth R. Venkatesh +7 more
wiley +1 more source
Stability-based approaches in chemoproteomics
Expert Reviews in Molecular MedicineTarget deconvolution can help understand how compounds exert therapeutic effects and can accelerate drug discovery by helping optimise safety and efficacy, revealing mechanisms of action, anticipate off-target effects and identifying opportunities for ...
Amy L. George +3 more
doaj +1 more source
Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors
Molecular Systems Biology, 2018 Novel therapies are undergoing clinical trials, for example, the Hsp90 inhibitor, XL888, in combination with BRAF inhibitors for the treatment of therapy‐resistant melanomas.
Alireza Azimi +15 more
doaj +1 more source
A guide to laser microdissection‐based proteomics
The FEBS Journal, EarlyView.This review takes researchers through the full laser microdissection proteomics workflow—from tissue preparation and image analysis to sample processing and mass spectrometry—offering practical solutions to common challenges at each step. Real‐world examples from across the field illustrate how the technology is being applied to disease tissue, making ...
Cheng Shen +3 more
wiley +1 more source
Thermal proteome profiling unveils protein targets of deoxycholic acid in living neuronal cells. [PDF]
Adv Biotechnol (Singap), 2023 Luan H, Li X, Zhang W, Luan T.
europepmc +1 more source
Life‐stage variation in Sable Shearwater (Ardenna carneipes) physiology assessed using proteomics
Ibis, EarlyView.Life‐stage transitions in seabirds involve substantial shifts in physiological demands, yet the molecular mechanisms underpinning these changes remain poorly resolved. Here we applied untargeted data‐independent acquisition mass spectrometry (DIA‐MS) to characterize and compare the plasma proteomes of fledgling and adult Sable Shearwaters Ardenna ...
Alix M. de Jersey +5 more
wiley +1 more source
Insect Molecular Biology, EarlyView.RNA‐seq and Batelli gland proteomics of fifth‐instar Mahanarva spectabilis nymphs reveal transcripts and proteins associated with xylem feeding, foam production and environmental interaction. Functional annotation identified genes involved in osmoregulation, detoxification, chemosensation and stress responses, while proteomic analysis confirmed ...
Monique da Silva Bonjour +8 more
wiley +1 more source
Development of a novel therapy for systolic heart failure
EMBO Molecular MedicineHeart failure presents a critical health challenge with a 5-year mortality rate of up to 50%. Conventional treatments often lead to bradycardia or hypotension due to their impact on patient hemodynamics. To address this issue, we utilized high-throughput
Corey Pollock +17 more
doaj +1 more source