Results 31 to 40 of about 27,136 (261)

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

A Thermal Comfort Evaluation Model for Contact Heat Transfer Based on Thermophysiology [PDF]

E3S Web of Conferences
This study integrates the Joint System Thermoregulation Model (JOS) with four different thermal sensation models to establish a thermophysiological-thermal sensation computational framework capable of handling complex contact heat transfer scenarios. The
Song Linye, Xia Haifeng, Zhou Xiang, Zeng Yingqi, Zhang Shuming   +4 more
doaj   +1 more source

Influence of Internal Structure and Composition on Head’s Local Thermal Sensation and Temperature Distribution

Atmosphere, 2020
A personalized thermal environment is an effective way to ensure a good thermal sensation for individuals. Since local thermal sensation and temperature distribution are affected by individual physiological differences, it is necessary to study the ...
Shuai He, Yinghua Zhang, Zhian Huang, Ge Zhang, Yukun Gao   +4 more
doaj   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Assessment of Thermal Environment in a Kitchen with a New Ventilation System [PDF]

E3S Web of Conferences, 2019
Chinese kitchen environment is usually hot and humid in summer and cold in winter, while housewife spends considerable time there. This investigation developed a new ventilation system for Chinese kitchens to improve thermal comfort level.
Liu Sumei, Zhou Xiaojie, Liu Xuan, Lin Xiaorui, Qing Ke, Zhang Weizhen, Li Jian, Dong Jiankai, Lai Dayi, Chen Qingyan   +9 more
doaj   +1 more source

The Thermal Responses between Young Adults and Preschool Children in a Radiant Floor Heating Environment

Buildings, 2022
The thermal comfort of preschool children was assumed to be similar to that of young adults, which may cause inaccuracy. This study tested and analyzed the thermal response characteristics of young adults and preschool children (4–6 years old) and the ...
Dong Liu, Na Liu, Donglin Ren, Xiaozhou Wu, Jun Wang, Yabin Tian, Anjie Hu, Li Wan, Jialan Wen   +8 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Modelling Residential Outdoor Thermal Sensation in Hot Summer Cities: A Case Study in Chongqing, China

Buildings, 2022
Exposure to extreme heat is a significant public health problem and the primary cause of weather-related mortality, which can be anticipated by accurately predicting outdoor thermal sensation.
Ying Liu, Yafeng Gao, Dachuan Shi, Chaoqun Zhuang, Zhang Lin, Zhongyu Hao   +5 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source