Results 51 to 60 of about 27,205 (257)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The Thermal Responses between Young Adults and Preschool Children in a Radiant Floor Heating Environment

Buildings, 2022
The thermal comfort of preschool children was assumed to be similar to that of young adults, which may cause inaccuracy. This study tested and analyzed the thermal response characteristics of young adults and preschool children (4–6 years old) and the ...
Dong Liu, Na Liu, Donglin Ren, Xiaozhou Wu, Jun Wang, Yabin Tian, Anjie Hu, Li Wan, Jialan Wen   +8 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Modelling Residential Outdoor Thermal Sensation in Hot Summer Cities: A Case Study in Chongqing, China

Buildings, 2022
Exposure to extreme heat is a significant public health problem and the primary cause of weather-related mortality, which can be anticipated by accurately predicting outdoor thermal sensation.
Ying Liu, Yafeng Gao, Dachuan Shi, Chaoqun Zhuang, Zhang Lin, Zhongyu Hao   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Determinación de los intervalos de confort y estrés térmico para espacios abiertos en la ciudad de Maringá (PR), Brasil, utilizando el índice PET

Desenvolvimento e Meio Ambiente, 2019
Prediction models of thermal comfort in open spaces are considered a fundamental tool in neighborhood planning, as well as in open space design within urban areas. However, most of these indices were developed for cold climates.
Mirna Milena Aquino, Paulo Fernando Soares, Carolina Lotufo Bueno-Bartolomei   +2 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Thermal sensations of secondary schoolchildren in summer [PDF]

Journal of Hygiene, 1973
SUMMARYSummer thermal sensations of secondary schoolchildren in England are compared with those earlier published for winter. Heat stress, contrary to expectation, is seen to decrease during the warm months, and neutrality is found to increase by some 6° F.
openaire   +4 more sources

Spatial structure of Yangzhou’ s old public bathrooms: a space syntax analysis of the topological characteristics of their unique sensory space

Journal of Asian Architecture and Building Engineering, 2023
Sensory experience is vital in creating a local identity in historical buildings and should ideally be conserved along with basic spatial structure. Hence, this study explores the relation between the spatial structure and thermal sensation experience by
Xing Chen, Wangteng Duan, Yi Liu, Shengcai Li, Shunyu Sui   +4 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source