Results 51 to 60 of about 32,150 (294)

Influence of Internal Structure and Composition on Head’s Local Thermal Sensation and Temperature Distribution

Atmosphere, 2020
A personalized thermal environment is an effective way to ensure a good thermal sensation for individuals. Since local thermal sensation and temperature distribution are affected by individual physiological differences, it is necessary to study the ...
Shuai He, Yinghua Zhang, Zhian Huang, Ge Zhang, Yukun Gao   +4 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Assessment of Thermal Environment in a Kitchen with a New Ventilation System [PDF]

E3S Web of Conferences, 2019
Chinese kitchen environment is usually hot and humid in summer and cold in winter, while housewife spends considerable time there. This investigation developed a new ventilation system for Chinese kitchens to improve thermal comfort level.
Liu Sumei, Zhou Xiaojie, Liu Xuan, Lin Xiaorui, Qing Ke, Zhang Weizhen, Li Jian, Dong Jiankai, Lai Dayi, Chen Qingyan   +9 more
doaj   +1 more source

Thermal comfort based fuzzy logic control

, 2001
Most heating, ventilation and air conditioning (HVAC) control systems are considered as temperature control problems. In this work, the predicted mean vote (PMV) is used to control the indoor temperature of a space by setting it at a point where the PMV ...
Underwood, Chris, Danaher, Sean, Gouda, M. M.   +2 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Spatial structure of Yangzhou’ s old public bathrooms: a space syntax analysis of the topological characteristics of their unique sensory space

Journal of Asian Architecture and Building Engineering, 2023
Sensory experience is vital in creating a local identity in historical buildings and should ideally be conserved along with basic spatial structure. Hence, this study explores the relation between the spatial structure and thermal sensation experience by
Xing Chen, Wangteng Duan, Yi Liu, Shengcai Li, Shunyu Sui   +4 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The Thermal Responses between Young Adults and Preschool Children in a Radiant Floor Heating Environment

Buildings, 2022
The thermal comfort of preschool children was assumed to be similar to that of young adults, which may cause inaccuracy. This study tested and analyzed the thermal response characteristics of young adults and preschool children (4–6 years old) and the ...
Dong Liu, Na Liu, Donglin Ren, Xiaozhou Wu, Jun Wang, Yabin Tian, Anjie Hu, Li Wan, Jialan Wen   +8 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source