Results 61 to 70 of about 78,560 (301)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
The influence of hot arid climate on the use of outdoor urban spaces and thermal comfort: do cultural and social backgrounds matter? [PDF]
, 2010 Climate-sensitive open spaces within cities may benefit the three dimensions of sustainability affecting economic, social and environmental factors. Aiming to improve microclimatic conditions in urban spaces can enable people to spend more time outdoors,
Aljawabra, Faisal +1 more
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Desenvolvimento e Meio Ambiente, 2019 Prediction models of thermal comfort in open spaces are considered a fundamental tool in neighborhood planning, as well as in open space design within urban areas. However, most of these indices were developed for cold climates.
Mirna Milena Aquino +2 more
doaj +1 more source
Journal of Asian Architecture and Building Engineering, 2023 Sensory experience is vital in creating a local identity in historical buildings and should ideally be conserved along with basic spatial structure. Hence, this study explores the relation between the spatial structure and thermal sensation experience by
Xing Chen +4 more
doaj +1 more source
What's new in mouth rinse nutrition? Update on fluid and menthol [PDF]
, 2018 This session will provide an update on the perceptual, physiological and performance effects of menthol mouth swilling during exercise performance, and the associated mechanisms underpinning these changes.
Best, Russell
core
Performance evaluation of ductless personalized ventilation in comparison with desk fans using numerical simulations [PDF]
, 2020 The performance of ductless personalized ventilation (DPV) was compared to the performance of a typical desk fan since they are both stand-alone systems that allow the users to personalize their indoor environment.
Alsaad, Hayder (Dr.-Ing.) +1 more
core
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
FEBS Open Bio, EarlyView.Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao +3 more
wiley +1 more source
Experimental Investigation of Indoor Thermal Comfort under Different Heating Conditions in Winter
Buildings, 2022 Owing to historical reasons, only a few locations in the Guangdong province use heating to enhance interior thermal conditions. With the variation in climate and increase in people’s lifestyle requirements, winter heating has become increasingly ...
Zhaosong Fang +4 more
doaj +1 more source