Results 61 to 70 of about 27,205 (257)

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Thermal sensation and comfort in transient non-uniform thermal environments [PDF]

European Journal of Applied Physiology, 2004
Most existing thermal comfort models are applicable only to steady-state, uniform thermal environments. This paper presents summary results from 109 human tests that were performed under non-uniform and transient conditions. In these tests, local body areas were independently heated or cooled while the rest of the body was exposed to a warm, neutral or
Zhang, Hui, Huizenga, Charlie, Arens, Edward, Wang, Danni   +3 more
openaire   +3 more sources

Thermal sensation of children and its predictive evaluation method in Indonesia’s dry season

Journal of Asian Architecture and Building Engineering
There is a discrepancy between children’s thermal sensation in hot-humid climates near the equator and conventional thermal comfort indexes, such as the predicted mean vote (PMV).
Masaya Kitaura, Ai Siti Munawaroh, Takeshi Iwata, Hisaya Nagai   +3 more
doaj   +1 more source

ASSESSMENT OF THERMAL SENSATION OF RESIDENTS IN THE SOUTHERN GREAT PLAIN, HUNGARY [PDF]

Aerul şi Apa: Componente ale Mediului, 2014
This study examines the subjective thermal sensation characteristics of people living in Szeged, in the Southern Hungarian Great Plain. Micrometeorological measurements were conducted with two mobile stations in six urban public spaces during 70 days ...
KOVÁCS A. , KÁNTOR NOÉMI, ÉGERHÁZI LILLA ANDREA   +2 more
doaj  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

The intensive summation of thermal sensations. [PDF]

Psychological Monographs, 1921
n ...
Baron, Annette, Bentley, Madison
openaire   +1 more source

TRPV1‐lineage neurons are required for thermal sensation [PDF]

The EMBO Journal, 2010
The ion-channel TRPV1 is believed to be a major sensor of noxious heat, but surprisingly animals lacking TRPV1 still display marked responses to elevated temperature. In this study, we explored the role of TRPV1-expressing neurons in somatosensation by generating mice wherein this lineage of cells was selectively labelled or ablated. Our data show that
Santosh K, Mishra, Sarah M, Tisel, Peihan, Orestes, Sonia K, Bhangoo, Mark A, Hoon   +4 more
openaire   +2 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Experimental study on overall and local thermal comfort under different radiation intensities [PDF]

E3S Web of Conferences
Shortwave radiation constitutes the principal source of thermal loading within automobile cabins, exhibiting characteristics of transient change and non-uniform distribution.
Zeng Yingqi, Zhou Xiang, Zhai Yongchao, Xia Haifeng   +3 more
doaj   +1 more source