Results 41 to 50 of about 1,091,843 (309)

A high temporal resolution global gridded dataset of human thermal stress metrics

Scientific Data
The human thermal stress indices and datasets are vital for promoting public health and reducing negative environmental impacts as global climate change and extreme meteorological events increase.
Hongdeng Jian, Zhenzhen Yan, Xiangtao Fan, Qin Zhan, Chen Xu, Weijia Bei, Jianhao Xu, Mingrui Huang, Xiaoping Du, Junjie Zhu, Zhimin Tai, Jiangtao Hao, Yanan Hu   +12 more
doaj   +1 more source

Heat Balance When Climbing Mount Everest

Frontiers in Physiology, 2021
Background: Mountaineers must control and regulate their thermal comfort and heat balance to survive the rigors of high altitude environment. High altitudes feature low air pressure and temperatures, strong winds and intense solar radiation, key factors ...
Robert K. Szymczak, Krzysztof Błażejczyk   +1 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Melatonin attenuates oxidative stress and modulates inflammatory response after experimental burn trauma [PDF]

, 2018
Introduction. Thermal injury activates an inflammatory response. Melatonin possesses anti-oxidant and anti-inflammatory properties. The objective of the present work was to study melatonin effects on the inflammatory response under ...
Atanasova, Milena, Bekyarova, Ganka, Hristova, Minka, Tzaneva, Maria   +3 more
core   +3 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Fundamental solution of thermal stress field in porous infinite media subjected to gas infiltration and heat transfer

Nihon Kikai Gakkai ronbunshu, 2014
When a porous solid is subjected to both gas infiltration and heat transfer, thermal stresses are generated in such a solid. In the previous reports, fundamental theory for a porous solid under such a complex situation was developed, and then a thermal ...
Masayuki ARAI
doaj   +1 more source

Rubber friction on smooth surfaces

, 2006
We study the sliding friction for viscoelastic solids, e.g., rubber, on hard flat substrate surfaces. We consider first the fluctuating shear stress inside a viscoelastic solid which results from the thermal motion of the atoms or molecules in the solid.
A. I. Volokitin, B. N. J. Persson, Baumberger, Casoli, Chernyak, Filippov, Gal, Grosch, Klüppel, Persson, Persson, Persson, Persson, Persson, Persson, Persson, Persson, Roberts, Schallamach, Schallamach, Tartaglino, vibrations, Vorvolakos, Williams   +23 more
core   +1 more source

Stability of pulse-like earthquake ruptures [PDF]

, 2019
Pulse-like ruptures arise spontaneously in many elastodynamic rupture simulations and seem to be the dominant rupture mode along crustal faults. Pulse-like ruptures propagating under steady-state conditions can be efficiently analysed theoretically, but ...
Beeler N. M., Day S. M., Lapusta N., Rice J. R., Trefethen L. N., Wald D. J., Zheng G.   +6 more
core   +3 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source