Results 51 to 60 of about 375,255 (310)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Air-Holes Collapse Properties of Photonic Crystal Fiber in Heating Process by
IEEE Photonics Journal, 2012 For the fusion splicing of photonic crystal fiber (PCF), the air-hole collapse in heating process is important for minimizing the splicing loss. To analyze the air-hole collapse properties in heating process by CO2 laser, a theoretical model of PCF has ...
G. Fu, W. Jin, X. Fu, W. Bi
doaj +1 more source
FEBS Open Bio, EarlyView.Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Thermal stresses in pipes [PDF]
, 2002 This study presents results about thermal stresses in externally heated pipes that are subjected to different flow types: laminar flow, turbulent flow, and pulsating flow. The effect o f flow Reynolds number on thermal stresses in the pipe is studied. To
Al-Zaharnah, Iyad
core
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
, 2017 Thermal ablation is a very important technique to characterize the thermal properties of coating systems. On account of the concentration of thermal stress, thermal barrier coatings (TBCs) often break off from the substrate partly or completely during ...
Ming Yang +13 more
core +1 more source
Frontiers in Marine ScienceContinuing global warming intensifies the thermal stress suffered by fish, urgently necessitating effective mitigating techniques. This study aims to investigate the mechanisms by which astaxanthin alleviates oxidative stress and inflammatory damage ...
Yulong Sun +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source