Results 41 to 50 of about 7,213,868 (243)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Potential Benefits of a Cosmetic Ingredient Combining Thermal Spring Water and Diatom Algae Extract
CosmeticsThe development of cosmetic ingredients improving the management of skin with irritation proclivity is an actual need. However, medical recommendations in specific cases, such as sensitive skin, include the use of as few and low-reactive ingredients as ...
Maria Lourdes Mourelle +4 more
doaj +1 more source
Preliminary results of radon survey in thermal spas in V4 countries
Nukleonika, 2016 Radon concentration was measured in 11 thermal spas in Visegrad countries (Czech Republic, Hungary, Poland, and Slovakia). The results showed that in 84% of spas radon activity concentration is less than 400 Bq·m−3.
Műllerová Monika +10 more
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Hydrogeological properties of the thermal source Rimske Toplice
Geologija, 2002 The Rimske Toplice thermal resort has been sadly abandoned since 1991. However, the mechanism of the thermal source is again earning greater attention of general public through recent efforts of Spa revitalisation.
Andrej Lapanje
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Use of thermal water as a natural coagulant for domestic wastewater sustainable treatment
Revista Facultad de Ingeniería, 2017 In the last several years, the interest on domestic wastewater treatment has increased due to the rise of water consumption resulted from the world population growth.
Javier Andrés Quintero-Jaramillo +2 more
doaj +1 more source
POSSIBLE ENVIRONMENTAL ASPECTS OF THERMAL WATER UTILISATION IN NORTH EAST HUNGARY [PDF]
Natural Resources and Sustainable Development, 2019 The reserves and exploitation of conventional, so-called fossil energy resources are limited, therefore the utilisation of renewable energy resources has been becoming more and more important.
Buday-Bódi Erika +4 more
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CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
POSSIBLE REDUCTION OF ENVIRONMENTAL IMPACTS OF GEOTHERMAL ENERGY EXTRACTION IN A THEORETICAL SPA [PDF]
Acta Geographica Debrecina. Landscape & Environment Series, 2015 Sustainable thermal water production involves the protection of the used reservoirs, as well as the minimizing of the environmental impact (caused by heat, gas and dissolved solid). Four water extraction models are discussed in which the water and heat
TAMÁS BUDAY
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