Results 91 to 100 of about 597,056 (294)

Functional fatigue in NiTi shape memory alloy wires - A comparative study [PDF]

open access: yes, 2012
The functional fatigue behaviour of two near equi-atomic NiTi shape memory alloy wires obtained from different sources were evaluated. Results showed that though the wires had similar transformation temperatures and mechanical properties, their ...
Ramaiah, KV   +3 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

OPTIMIZATION OF STEEL SATURATION PROCESSES USING CARBIDE-FORMING ELEMENTS IN SYSTEMS BASED ON Cr-Ti-V AND Cr-Ti-Mn

open access: yesНаука и техника, 2007
Optimization of saturating mixture compositions has been carried out in two three-component systems, namely: Cr-Ti-V and Cr-Ti-Mn in respect of micro-hardness and wear resistance of carbide coatings obtained by thermo-chemical treatment of high carbon ...
A. A. Shmatov
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Fatigue life of bioactive titanium dental implants treated by means of grit-blasting and thermo-chemical treatment

open access: yes, 2014
Objective: This study focuses on the fatigue behavior of titanium dental implants as-received, with a grit-blasted surface and with a new bioactive surface treatment (2Steps). Background: The 2Step process consists of (1) an initial grit-blasting process
Jose Maria Llamas   +7 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

Physical and Chemical Water Quality of Ilam Water Treatment Plant [PDF]

open access: yes
Water usually has some dissolved elements such as solids and gasses. Existences of some elements in water are necessary for human health, but deficiency of many them can cause problems.
تردست, علی   +6 more
core  

Residual stresses and fatigue resistance of toothed wheels

open access: yesВестник Самарского университета: Аэрокосмическая техника, технологии и машиностроение, 2018
Residual stresses in the dangerous section of toothed wheels made of materials and according to practices accepted in aviation engine construction have been determined using a mechanical method. The influence of the technology of manufacturing of toothed
V. S. Vakulyuk   +3 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

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