Results 71 to 80 of about 597,056 (294)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Effort to improve coupled in situ chemical oxidation with bioremediation: a review of optimization strategies

open access: yes, 2011
Purpose - In order to provide highly effective yet relatively inexpensive strategies for the remediation of recalcitrant organic contaminants, research has focused on in situ treatment technologies. Recent investigation has shown that coupling two common
Rijnaarts, H.H.M.   +3 more
core   +1 more source

Effect of Novel Thermo-Chemical Treatment on Bending Strength of Laminated Glass [PDF]

open access: yesInternational Journal of Structural Glass and Advanced Materials Research, 2018
The science of thermal and chemical treatment of glass is well documented. The Laminated Glass (LG) is usually not treated as either treated glass is used during production or lower melting temperature of interlayer does not allow the treatment. The present work reports the novel methods of thermo-chemical treatment of LG having annealed soda lime ...
openaire   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Enhancement of Biogas production and organic reduction of sludge by different pre-treatment processes

open access: yesIraqi Journal of Chemical and Petroleum Engineering, 2012
Anaerobic digestion (AD) is the most common process for dealing with primary and secondary wastewater sludge. In the present work, four pre-treatment methods (ultrasonic, chemical, thermal, and thermo-chemical) are investigated in Al-Rustumya Wastewater ...
Riyadh S. Almukhtar   +2 more
doaj  

Changing Properties of Metal Surface Layers during Thermo-Chemical Treatment

open access: yesActa Physica Polonica A, 1999
In this article a two-stage technology for constituting surface layers is proposed. First, the material is subjected to initial hardening by burnishing and next to a nitriding process. The surface layer after such processing should have considerably better strength properties compared to those created through a conventional nitriding process.
G. Wróblewski, K. Skalski, R. Piekarski
openaire   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

The Evolution of the Characteristics of Mechanical Resistance for the Nitro-Carburrized Treated Steel, after Thermo-Magnetic Treatment

open access: yesThe Annals of “Dunarea de Jos” University of Galati. Fascicle IX, Metallurgy and Materials Science, 2014
The aim of the research was to study the evolution of the characteristics of mechanical resistance for one type of steel. The material was subjected to the thermo-chemical (nitro-carburized treatment in plasma) treatment applied after thermo- magnetic ...
Carmen Penelopi PAPADATU
doaj  

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