Results 111 to 120 of about 12,961 (242)

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Influence of thermophoresis and Brownian motion on Sherwood number.

, 2017
Influence of thermophoresis and Brownian motion on Sherwood number.
Maria Nawaz (3611339), Muhammad Awais (263096), M. M. Rashidi (3611336), Z. Yang (1300311), Tasawar Hayat (433317)   +4 more
core   +1 more source

Structural Elucidation and Engineering of the (S)‐scoulerine 2‐O‐Methyltransferase Enabling Regioselective Epiberberine Biosynthesis in Coptis chinensis

Plant Biotechnology Journal, Volume 24, Issue 7, Page 4528-4545, July 2026.
ABSTRACT Protoberberine alkaloids are a characteristic group of natural products in Coptis plants known for their notable pharmacological activities. However, the structural similarity and the substrate promiscuity of their biosynthetic enzymes have left the precise synthetic pathways remain unclarified, posing challenges to regulate product formation.
Jun Song, Di Liu, Shi Chen, Yufeng Tan, Siyu Wang, Shihan Li, Yutong Qin, Guofeng Li, Xufang Tian, Lan Yang, Chong Yuan, Junbo Gou, Wei Huang, Shilin Chen, Yifei Liu   +14 more
wiley   +1 more source

Mechanism of Polymer Thermophoresis in Nonaqueous Solvents

, 2000
The thermophoresis of homopolymer chains dissolved in a pure nonelectrolyte solvent is theoretically examined. Using a similar approach to that used for suspended particles, thermophoresis is related to the temperature-dependent osmotic pressure ...
Schimpf, Martin E., Semenov, Semen N.
core   +1 more source

Effects of wall slip and nanoparticles' thermophoresis on the convective heat transfer enhancement of nanofluid in a microchannel

Journal of Thermal Science and Technology, 2016
Heat transfer enhancement with nanofluid appears to be an attractive work in recent years. In present work, a numerical formulation based on the Buongiorno model for convective heat transfer using Al2O3-water nanofluid accounted for the effects of ...
Ruijin WANG, Jiayou DU, Zefei ZHU
doaj   +1 more source

Metabolic Reprogramming of a Phenolic Acid by a Plant P450 Monooxygenase Reverses Bacterial Immunosuppression

Plant Biotechnology Journal, Volume 24, Issue 7, Page 4672-4688, July 2026.
Ralstonia solanacearum suppresses P450 activity to block VA‐to‐VanA conversion, leading to VA accumulation and compromised immunity. ABSTRACT Soil acidification often exacerbates plant diseases caused by soil‐borne pathogens like Ralstonia solanacearum, but the underlying molecular mechanisms remain elusive. This study unveils a sophisticated metabolic
Hua Wang, Xiaoshuang Peng, Xinrui Wang, Ruiyu Yang, Tao Liu, Huidi Liu, Chao Zhao, Hong Zhou, Liang Yang, Shili Li, Wei Ding   +10 more
wiley   +1 more source

Concentration profile for variation in thermophoresis parameter when , and

, 2014
Concentration profile for variation in thermophoresis parameter when , and
Fuad Alsaadi (659022), Fahad Munir Abbasi (552373), Sabir Ali Shehzad (433315), Tasawar Hayat (433317)   +3 more
core   +1 more source

Click Capture SELEX for the Identification of Click‐Modified Aptamers Targeting Small Molecules in Solution

Chemistry – A European Journal, Volume 32, Issue 23, 16 June 2026.
Using kanamycin A as a model target, we developed click‐capture SELEX to identify nucleobase‐modified aptamers capable of binding small molecules in solution. This approach enables flexible incorporation of nucleobase modifications via CuAAC, allowing the chemical properties of the aptamer to be tailored to the target molecule.
Philipp Menke, Carmelo Di Primo, Felix Bernhardt, Alea Schröder, Christian Renzl, Günter Mayer   +5 more
wiley   +1 more source

Conductometric Soot Sensors: Internally Caused Thermophoresis as an Important Undesired Side Effect

Sensors, 2018
Particulate matter sensors are of interest for application in the exhaust of any combustion processes, especially for automotive aftertreatment systems. Conductometric soot sensors have been serialized recently.
Gunter Hagen, Christoph Spannbauer, Markus Feulner, Jaroslaw Kita, Andreas Müller, Ralf Moos   +5 more
doaj   +1 more source

Structure‐Based Design, Synthesis, and Evaluation of Novel Ponatinib Derivatives With a Significantly Altered Selectivity Profile

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
We developed new derivatives of the cancer drug ponatinib, significantly reducing and altering its spectrum of target kinases. Compound 5 retained the efficacy in inhibiting the colony formation of MDA‐MB‐231 cells and acted primarily on B‐Raf and Flt‐1 as its main targets in a kinase panel.
Tobias Betzholz, Ting Liu, Andreas Krämer, Verena Dederer, Stefan Knapp, Sebastian Mathea, Christian Ducho, Matthias Engel   +7 more
wiley   +1 more source