Results 101 to 110 of about 6,323 (216)

Uniform Microscale Thermoresponsive Liposomes for Controlled Release Above Body Temperature

Small, EarlyView.
Uniform thermoresponsive liposomes are generated using a scalable double‐emulsion microfluidic approach coupled with accelerated solvent extraction. The resulting liposomes remain stable at physiological temperature but undergo abrupt rupture and cargo release at 41°C–45°C, providing a versatile platform for thermally triggered controlled release in ...
S. Morteza Mousavi, Yang Zhang, Elvis Pandzic, David W. Inglis, Megan S. Lord, Robert A. Taylor, Ming Li   +6 more
wiley   +1 more source

Topology‐Encoded Charge Polarity Governs Multiphase Organization in Intrinsically Disordered Protein Polymer Condensates

Small, EarlyView.
Electrostatic topology is shown to program phase separation and internal organization in thermoresponsive intrinsically disordered protein polymer (IDPP) condensates. By comparing oppositely charged IDPPs with a covalent diblock, chain connectivity is revealed to control charge compensation, dense‐phase micropolarity, miscibility, and apparent acid ...
Julio Fernández‐Fernández, Vicente Domínguez‐Arca, Raúl Escribano, Sheila Lorenzo, Sergio Ferrero, Sergio Acosta, José Carlos Rodríguez‐Cabello   +6 more
wiley   +1 more source

Fabrication and in vitro evaluation of pH/thermo dual responsive hydrogels as controlled ibuprofen sodium in situ depot

Designed Monomers and Polymers
Ibuprofen sodium (IBP) is a commonly used NSAID for multiple pain conditions. However, despite its extensive use, it is associated with multiple GIT adverse effects after oral administration.
Samiullah Khan, Abdur Rehman, Syed Faisal Badshah, Gamal A. Shazly, Amira Metouekel, Fakhreldeen Dabiellil   +5 more
doaj   +1 more source

Reconciling Granular Hydrogel Microstructure and Mechanics via a Temporary Thermo‐Responsive and Cell‐Invadable Matrix

Small, EarlyView.
Thermo‐responsive granular hydrogels (TRGHs), composed of microparticles and an interstitial matrix, exhibit thermo‐responsive mechanical properties and allow cell infiltration. This system effectively addresses the conventional compromise between mechanical strength and porosity observed in granular hydrogels.
Jun Kim, Soyeon Kwon, Taimoor H. Qazi
wiley   +1 more source

Suspension Photopolymerization of Methyl Methacrylate and ATRP Grafting of Thermo‐Responsive Polymers Using a Perylediimide Derivative Photoinitiator

Macromolecular Materials and Engineering
The first aim of this study is to develop a photo‐ATRP process using methyl methacrylate (MMA) by employing a novel perylenediimide derivative (PDI) as photoinitiator.
Aurel Diacon, Florica Rizea, Alexandra Mocanu, Adrian Dinescu, Cristina Stavarache, Luiza Izabela Jinga, Cristian N. Mihăilescu, Edina Rusen   +7 more
doaj   +1 more source

Mystery and misery of locally‐delivered drug therapy in periodontics. Historical concepts and current state

Periodontology 2000, EarlyView.
Abstract The primary objective is to critically analyze approaches to local therapy for periodontal disease, particularly in light of its well‐established systemic implications. We specifically address common misconceptions and overestimations regarding the potential of local treatments in contrast to their actual clinical effectiveness.
Andrea Mombelli, Alkisti Zekeridou
wiley   +1 more source

Temperature-modulated interactions between thermoresponsive strong cationic copolymer-brush-grafted silica beads and biomolecules

Heliyon
Thermoresponsive polymer brushes have attracted considerable research attention owing to their unique properties. Herein, we developed silica beads grafted with poly(N-isopropylacrylamide (NIPAAm)-co-3-acrylamidopropyl trimethylammonium chloride (APTAC ...
Kenichi Nagase, Sayaka Suzuki, Hideko Kanazawa   +2 more
doaj   +1 more source

Engineered surface strategies to manage dental implant‐related infections

Periodontology 2000, EarlyView.
Abstract When exposed to the oral environment, dental implants, like natural surfaces, become substrates for microbial adhesion and accumulation, often leading to implant‐related infections—one of the main causes of implant failure. These failures impose significant costs on patients, clinicians, and healthcare systems.
João Gabriel S. Souza, Bruna E. Nagay, Rodrigo Martins, Martinna Bertolini, Jamil A. Shibli, Conrado Aparicio, Magda Feres, Valentim A. R. Barão   +7 more
wiley   +1 more source

A New Way to Engineer Cell Sheets for Articular Cartilage Regeneration

Journal of Functional Biomaterials
Background: Articular cartilage has limited self-repair capacity. While thermoresponsive poly N-isopropyl acrylamide (pNIPAAm)-based Cell Sheet Engineering (CSE) is a promising scaffold-free strategy, its inherent material properties pose limitations ...
Ta-Lun Tan, Yuan Tseng, Jia-Wei Li, Cheng-Tse Yang, Hsuan-Yu Chen, Her-I Lee, Jun-Jen Liu, Yi-Yuan Yang, How Tseng   +8 more
doaj   +1 more source

Surviving the Nucleus Pulposus Desert: Next‐Generation Strategies for Intervertebral Disc Cell Therapy

JOR SPINE, Volume 9, Issue 3, September 2026.
ABSTRACTBackgroundLow back pain remains the leading cause of disability worldwide, with intervertebral disc degeneration representing a major biological contributor. Although cell‐based therapies have shown promise in preclinical models, clinical translation has yielded modest and inconsistent outcomes.
Tynhinane Hamidouche, Namdev More, Tiffany Lee, Mia Orr, Anne Camus, Devina Purmessur, Sarah E. Gulbrand, Nadeen O. Chahine, Lara Silverman, Dmitriy Sheyn   +9 more
wiley   +1 more source