Results 181 to 190 of about 889,903 (281)

Cell‐Based Micro/Nanorobots: From Living Carriers to Living Therapeutic Specialists

SmartBot, EarlyView.
Cell‐based micro/nanorobots integrate evolutionarily acquired biological intelligence with engineered capabilities, offering new opportunities for precision medicine in vivo. However, the complex physiological environments of different organs pose significant challenges to their clinical translation.
Junfeng Wu, Zhaoyu Zhang, Ke Xu, Enkuo Li, Yuting Cui, Yuting Zhou, Huanyu Zhou, Beipei Zhang, Shuai Jiang, Xiaodong Wang, Jialin Jiang, Lianqing Liu, Niandong Jiao   +12 more
wiley   +1 more source

Thermosensitive Nanostructured Coacervates Developed by Mixing ABA‐ and AB‐Block Copolymers and Their Unique Sustained Release of Nano‐Micelles in a Regulated Manner

Small, EarlyView.
Polyion complex micelles composed of blends of ABA and AB block copolymers can form coacervates with a hexagonally packed cylinder nanostructure after heating. The resulting coacervates can release the micelles under physiological conditions in a zero‐order kinetics, possessing cargo proteins.
Takumi Egashira, Hiroshi Kamizawa, Yujiro Hamada, Wataru Fushimoto, Hiroshi Y. Yoshikawa, Yuji Higaki, Atsushi Takahara, Takeshi Mori, Yoshiki Katayama, Akihiro Kishimura   +9 more
wiley   +1 more source

Sprayable MXene Hydrogels With Composition‐Driven Interfacial Stabilization and on‐Skin Gelation for Conformal Postsurgical Photothermal Therapy

Small, EarlyView.
A sprayable MXene‐loaded thermosensitive hydrogel was developed for postoperative melanoma treatment. Molecular simulations combined with experimental analyses demonstrated that polymer composition regulates MXene oxidation. The optimized hydrogel effectively preserved photothermal performance under physiological conditions, enabling efficient near ...
Taek Hwang, Soojin Ko, Byeongjun Jeon, SeongHoon Jo, Soonjong Roh, Yeonju Song, Yu‐Jin Kim, Seok Hyeon Kim, Seong Ryeol Ye, Jin Hoon Kim, Dae Woo Kim, Hyojin Lee, Youngmee Jung, Bumjoon Seo, Seon Joon Kim, Jin Yoo   +15 more
wiley   +1 more source

Induced Core‐Shell Transformation in Agarose‐Chitosan Nanoreactor Beads Enable Single Channel Coding for dPCR Multiplexing

Small, EarlyView.
Hybrid agarose–chitosan beads undergo a pH‐dependent reorganization into stable core–shell structures upon heating. The resulting tunable optical shell/core contrasts enable bead‐based coding for multiplex PCR. This approach allows sample multiplexing with simple detection systems and functionally exploits a previously unrecognized structure‐forming ...
Katharina Heise, Lennart Gura, Emma Pohl, Lea Kanitz, Theresa Liebe, Daniel Toro, Katrin Steinmetzer, Thomas Ellinger, Susanne Klingner, Stephan Hubold, Oliver Lemuth, Susanne Töpfer, Eugen Ermantraut   +12 more
wiley   +1 more source

Interface‐Directed Self‐Assembly of Thermoresponsive Block Copolymers for Tunable Interfacial Nanostructures

Small, EarlyView.
Surface pressure and temperature direct the assembly of P(NIPAM‐b‐AEMA) at the air‐water interface, transforming continuous films into tunable micellar nanodomains. The thermoresponsive P(NIPAM) block enables temperature‐controlled changes in domain size and order.
Miriam Peña‐Figueroa, Armando Maestro, Ester Verde‐Sesto, Alberto Alvarez‐Fernandez   +3 more
wiley   +1 more source

Multi‐Scale 3D Printing of Magnetic Polymer Nanocomposites with Controlled Particle Dispersion and Hyperthermic Response

Small, EarlyView.
Dispersion of magnetic nanoflowers in trimethylolpropane ethoxylate triacrylate to generate photocurable nanocomposites is described. Particle dispersion provides processability and target AC‐field stimulated temperature increases. Complex (DLP) printed structures with submicron features are demonstrated, and the potential for stimulated release of ...
Eoin P. McKiernan, Jacek K. Wychowaniec, Danielle Winning, Shane Clerkin, Ines Martinez‐‐Chauvin, John Crean, Alexa Ennis, Colm Delaney, Larisa Florea, Dermot F. Brougham   +9 more
wiley   +1 more source

Smart mesoporous silica nanoparticles for precision cancer therapy: Tumor targeting and stimuli‐responsive controlled release

Smart Molecules, EarlyView.
Smart mesoporous silica nanoparticles integrate tunable pore structures, molecular gates, targeting ligands, and stimuli‐responsive components to achieve controlled drug release for precision cancer therapy. This review highlights design principles, therapeutic applications, and future directions in immunotherapy, biodegradability, biosafety, and ...
Majdi Al‐Amili, Lei Lei, Zhu Jin
wiley   +1 more source

Optical Control of Therapeutic Synthetic Cells: Controlling Biomolecule Synthesis, Activation, and Communication

Small Methods, EarlyView.
Combining synthetic cells engineering, cell‐free expression, and optical regulation may enable a new generation of programmable synthetic cell platforms. By providing spatiotemporal control over biomolecule synthesis, activation, transport, release, and communication, light offers a versatile strategy for coordinating proteins, RNAs, peptides, and ...
Gia Bao Leon Hoang, Taniya Chakraborty
wiley   +1 more source

Four‐dimensional immuno‐mechanobiomaterials: Dynamic material cues that program host response to prevent fibrosis and enable regeneration

VIEW, EarlyView.
Dynamic immuno‐mechanobiomaterials with time‐programmed mechanical adaptation orchestrate host responses through precise mechanotransduction and immune‐stromal regulation. These adaptive biomaterials minimize mechanical mismatch, attenuate the forign dy response and fibrosis, promote angiogenesis and controlled extracellular matrix remodeling, and ...
Gobinath Vellapalayam Manoharan, Kathirvel Ayyaswamy, Parthasarathy Vellaichamy, Nagarajan Deivanayagam Pillai, Rithik Gobinath   +4 more
wiley   +1 more source

Mystery and misery of locally‐delivered drug therapy in periodontics. Historical concepts and current state

Periodontology 2000, EarlyView.
Abstract The primary objective is to critically analyze approaches to local therapy for periodontal disease, particularly in light of its well‐established systemic implications. We specifically address common misconceptions and overestimations regarding the potential of local treatments in contrast to their actual clinical effectiveness.
Andrea Mombelli, Alkisti Zekeridou
wiley   +1 more source