Results 221 to 230 of about 33,156 (309)

Liposomal Nanoparticulate Drug Delivery Systems: Strategies to Destabilize Biological Membranes at the Target Tissue. [PDF]

Int J Nanomedicine
Wang J, Ahmed KS, Ahmed KS, Pan P, Thakur SS, Wu Z.   +5 more
europepmc   +1 more source

Thermo‐tone: A newly revealed mechanism of blood flow regulation

Experimental Physiology, EarlyView.
Abstract Myogenic tone enables dynamic control of tissue blood flow. This intrinsic property of vascular smooth muscle cells to sense stretch and reflexively adjust the calibre of small arteries is crucial to maintain capillary pressure and a blood flow reserve. For over 120 years blood pressure was considered the sole determinant of myogenic tone. Our
Thieu X. Phan, Gerard P. Ahern
wiley   +1 more source

Enhanced Antitumor Effects by Docetaxel/LL37-Loaded Thermosensitive Hydrogel Nanoparticles in Peritoneal Carcinomatosis of Colorectal Cancer [Retraction]. [PDF]

Int J Nanomedicine
europepmc   +1 more source

Development of an injectable thermosensitive hydrogel depot system for controlled and sustained subcutaneous drug delivery. [PDF]

Int J Pharm X
Vu QL, Chiu IH, Do LT, Nguyen TP, Nguyen TH, Thanh DV, Suhail M, Wu PC.   +7 more
europepmc   +1 more source

TRPM8 and TRPM2 ion channels determine sex differences in thermal preference in mice

The Journal of Physiology, EarlyView.
Abstract figure legend Too hot or too cold? How do we know? Animals seek a ‘comfort temperature’ in between ‘too hot’ (far left) and ‘too cold’ (far right). In mammals and birds, females (left) prefer warmer temperatures than males (right). We show here that in mice, the comfort temperature is determined by a balance of sensory input (black arrows ...
Bruno Vilar, Peter A. McNaughton
wiley   +1 more source

Preparation of a Thermosensitive Chitosan-Sea Cucumber Peptide Hydrogel and Its Alleviating Effect on Acute Alcohol-Induced Dual Liver and Brain Injury in Mice. [PDF]

Mar Drugs
Guo J, Kong S, Chen C, Lu G, Li Z, Chen J, Liang M.   +6 more
europepmc   +1 more source

The interplay between dynamic regulation of ion‐channel gating and trafficking in cardiac arrhythmogenesis

The Journal of Physiology, EarlyView.
Abstract figure legend Cardiac cellular electrophysiology is modulated by multiple factors, including temperature, extracellular K+, heart rate/pacing frequency, and drugs. These modulators can have distinct effects on ion‐channel gating and transcription/trafficking over time.
Stefan Meier, Anna S. Savchenko, Paul G. A. Volders, Jordi Heijman   +3 more
wiley   +1 more source

Fabrication and characterization of PIB gels as effective adsorbents for methylene blue. [PDF]

RSC Adv
Peng X, Zhu H, Wu J, Ding J, Luo B.
europepmc   +1 more source

Low‐threshold cutaneous mechanoreceptors on the foot sole have enhanced sensitivity when skin temperature is elevated

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustration of microneurography recordings used to examine the effects of local skin heating on cutaneous mechanoreceptor responses in the human foot (left panel). A microelectrode inserted into a peripheral nerve records single‐unit activity from tactile afferent fibres while controlled mechanical stimuli are applied ...
Erika E. Howe, Michael Apollinaro, Joanna Reeves, Christopher Nester, Leah R. Bent   +4 more
wiley   +1 more source

QbD Approach for Development of a Mucoadhesive Thermosensitive Gel for Oral Application: Risk Assessment Followed by Screening and Optimization. [PDF]

Gels
Dinte E, Tomuță I, Iovanov RI, Casian T, Achim AM, Ilea A, Bosca AB, Rotar H.   +7 more
europepmc   +1 more source